TY - JOUR
T1 - The CONSTANCES Cohort Biobank
T2 - An Open Tool for Research in Epidemiology and Prevention of Diseases
AU - Henny, J.
AU - Nadif, R.
AU - Got, S. Le
AU - Lemonnier, S.
AU - Ozguler, A.
AU - Ruiz, F.
AU - Beaumont, K.
AU - Brault, D.
AU - Sandt, E.
AU - Goldberg, M.
AU - Zins, M.
N1 - Funding Information:
The Constances Cohort Study was supported and funded by the Caisse nationale d’assurance maladie (CNAM). The Constances Cohort Study is an Infrastructure nationale en Biologie et Santé and benefits from a grant from ANR (ANR-11-INBS-0002) and from the Ministry of Research. Constances is also partly funded by MSD, AstraZeneca and Lundbeck.
Funding Information:
The authors thank the Caisse nationale d'assurance maladie (CNAM) and the Centres d'examens de sant? of the French Social Security which are collecting a large part of the data, as well as the Caisse nationale d'assurance vieillesse, ClinSearch, Asqualab and Eurocell in charge of the data quality control. The authors thank all those who participated to the setting of the study and on the various aspects of the examinations involved: interviewers, technicians for lung function testing and neuropsychologists, coders, those involved in quality control, data and sample management and all the staffs from the inclusion centers (HPCs). They are indebted to all the participating individuals without whom the study would not have been possible. Funding. The Constances Cohort Study was supported and funded by the Caisse nationale d'assurance maladie (CNAM). The Constances Cohort Study is an Infrastructure nationale en Biologie et Sant? and benefits from a grant from ANR (ANR-11-INBS-0002) and from the Ministry of Research. Constances is also partly funded by MSD, AstraZeneca and Lundbeck.
Publisher Copyright:
© Copyright © 2020 Henny, Nadif, Got, Lemonnier, Ozguler, Ruiz, Beaumont, Brault, Sandt, Goldberg and Zins.
PY - 2020/12/10
Y1 - 2020/12/10
N2 - “General-purpose cohorts” in epidemiology and public health are designed to cover a broad scope of determinants and outcomes, in order to answer several research questions, including those not defined at study inception. In this context, the general objective of the CONSTANCES project is to set up a large population-based cohort that will contribute to the development of epidemiological research by hosting ancillary projects on a wide range of scientific domains, and to provide public health information. CONSTANCES was designed as a randomly selected sample of French adults aged 18–69 years at study inception; 202,045 subjects were included over an 8-year period. At inclusion, the selected participants are invited to attend one of the 24 participating Health Prevention Centers (HPCs) for a comprehensive health examination. The follow-up includes a yearly self-administered questionnaire, and a periodic visit to an HPC. Procedures have been developed to use the national healthcare databases to allow identification and validation of diseases over the follow-up. The biological collection (serum, lithium heparinized plasma, EDTA plasma, urine and buffy coat) began gradually in June 2018. At the end of the inclusions, specimens from 83,000 donors will have been collected. Specimens are collected according to a standardized protocol, identical in all recruitment centers. All operations relating to bio-banking have been entrusted by Inserm to the Integrated Biobank of Luxembourg (IBBL). A quality management system has been put in place. Particular attention has been paid to the traceability of all operations. The nature of the biological samples stored has been deliberately limited due to the economic and organizational constraints of the inclusion centers. Some research works may require specific collection conditions, and can be developed on request for a limited number of subjects and in specially trained centers. The biological specimens that are collected will allow for a large spectrum of biomarkers studies and genetic and epigenetic markers through candidate or agnostic approaches. By linking the extensive data on personal, lifestyle, environmental, occupational and social factors with the biomarker data, the CONSTANCES cohort offers the opportunity to study the interplays between these factors using an integrative approach and state-of-the-art methods.
AB - “General-purpose cohorts” in epidemiology and public health are designed to cover a broad scope of determinants and outcomes, in order to answer several research questions, including those not defined at study inception. In this context, the general objective of the CONSTANCES project is to set up a large population-based cohort that will contribute to the development of epidemiological research by hosting ancillary projects on a wide range of scientific domains, and to provide public health information. CONSTANCES was designed as a randomly selected sample of French adults aged 18–69 years at study inception; 202,045 subjects were included over an 8-year period. At inclusion, the selected participants are invited to attend one of the 24 participating Health Prevention Centers (HPCs) for a comprehensive health examination. The follow-up includes a yearly self-administered questionnaire, and a periodic visit to an HPC. Procedures have been developed to use the national healthcare databases to allow identification and validation of diseases over the follow-up. The biological collection (serum, lithium heparinized plasma, EDTA plasma, urine and buffy coat) began gradually in June 2018. At the end of the inclusions, specimens from 83,000 donors will have been collected. Specimens are collected according to a standardized protocol, identical in all recruitment centers. All operations relating to bio-banking have been entrusted by Inserm to the Integrated Biobank of Luxembourg (IBBL). A quality management system has been put in place. Particular attention has been paid to the traceability of all operations. The nature of the biological samples stored has been deliberately limited due to the economic and organizational constraints of the inclusion centers. Some research works may require specific collection conditions, and can be developed on request for a limited number of subjects and in specially trained centers. The biological specimens that are collected will allow for a large spectrum of biomarkers studies and genetic and epigenetic markers through candidate or agnostic approaches. By linking the extensive data on personal, lifestyle, environmental, occupational and social factors with the biomarker data, the CONSTANCES cohort offers the opportunity to study the interplays between these factors using an integrative approach and state-of-the-art methods.
KW - DNA
KW - biobanking methodology
KW - biorepository
KW - blood samples
KW - longitudinal studies
KW - observational studies
KW - population-based cohort
KW - urine samples
UR - http://www.scopus.com/inward/record.url?scp=85098104931&partnerID=8YFLogxK
U2 - 10.3389/fpubh.2020.605133
DO - 10.3389/fpubh.2020.605133
M3 - Article
C2 - 33363097
AN - SCOPUS:85098104931
SN - 2296-2565
VL - 8
JO - Frontiers in Public Health
JF - Frontiers in Public Health
M1 - 605133
ER -