The COMT Val/Met polymorphism modulates effects of tDCS on response inhibition

Vanessa Nieratschker, Christoph Kiefer, Katrin Giel, Rejko Krüger, Christian Plewnia*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)


Background: Transcranial direct current stimulation (tDCS) is increasingly discussed as a new option to support the cognitive rehabilitation in neuropsychiatric disorders. However, the therapeutic impact of tDCS is limited by high inter-individual variability. Genetic factors most likely contribute to this variability by modulating the effects of tDCS. Objectives: We aimed to investigate the influence of the COMT Val(108/158)Met polymorphism on cathodal tDCS effects on executive functioning. Methods: Cathodal tDCS was applied to the left dorsolateral prefrontal cortex (dlPFC) during the performance of a parametric Go/No-Go test. Results: We demonstrate an impairing effect of cathodal tDCS to the dlPFC on response inhibition. This effect was only found in individuals homozygous for the Val-allele of the COMT Val(108/158)Met polymorphism. No effects of stimulation on executive functions in Met-allele carriers were detected. Conclusion: Our data indicate that i) cathodal, excitability reducing tDCS, interferes with inhibitory cognitive control, ii) the left dlPFC is critically involved in the neuronal network underlying the control of response inhibition, and iii) the COMT Val(108/158)Met polymorphism modulates the impact of cathodal tDCS on inhibitory control. Together with our previous finding that anodal tDCS selectively impairs set-shifting abilities in COMT Met/Met homozygous individuals, these results indicate that genetic factors modulate effects of tDCS on cognitive performance. Therefore, future tDCS research should account for genetic variability in the design and analysis of neurocognitive as well as therapeutic applications to reduce the variability of results and facilitate individualized neurostimulation approaches.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalBrain Stimulation
Issue number2
Publication statusPublished - 1 Mar 2015
Externally publishedYes


  • Brain stimulation
  • COMT
  • Catechol-O-methyltransferase
  • Dopamine
  • Genetics
  • Response inhibition


Dive into the research topics of 'The COMT Val/Met polymorphism modulates effects of tDCS on response inhibition'. Together they form a unique fingerprint.

Cite this