The Chemokine (C-X3-C Motif) Receptor 1 is a Candidate Prognostic Biomarker after Cardiac Arrest

P Stammet, M Kirchmeyer, L Zhang, D Wagner, Y Devaux*

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review


    Background: Early prediction of outcome after cardiac arrest (CA) may influence treatment strategies. Existing biomarkers are of limited value. Therefore, we sought to determine whether analysis of the transcriptome of circulating blood cells may help to predict outcome after CA.
    Methods: Consecutive comatose patients resuscitated after CA and treated with hypothermia were enrolled in this study. Blood samples were drawn 48 hours after CA for gene expression analyses by microarrays and quantitative PCR. Neurological outcome at 6 months was evaluated using the cerebral performance category (CPC). Patients with CPC 1-2 were considered having favorable neurological outcome, whereas patients with CPC 3-5 were considered as having poor outcome.
    Results: The initial cohort consisted of 35 patients. Microarrays revealed a biosignature associated with neurological outcome after CA. 582 genes were differentially expressed between patients with favorable neurological outcome (n=21) and patients with poor neurological outcome (n=14). Bioinformatic analyses revealed significant associations between these genes and neuronal damage. Prediction analysis of microarrays identified the chemokine (C-X3-C motif) receptor 1 (CX3CR1) as a candidate prognostic biomarker. CX3CR1 was up-regulated in patients with favorable outcome (2-fold, PConclusion: We identified CX3CR1 as a new candidate prognostic biomarker after CA. Further studies are required to confirm its predictive value.
    Original languageEnglish
    Article numberS2-004
    JournalJournal of Clinical & Experimental Cardiology
    Issue numberSI
    Publication statusPublished - 2 Apr 2012


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