The B-side of cancer immunity: The underrated tune

Research output: Contribution to journalReview articlepeer-review

69 Citations (Scopus)

Abstract

Tumor-infiltrating lymphocytes are known to be critical in controlling tumor progression. While the role of T lymphocytes has been extensively studied, the function of B cells in this context is still ill-defined. In this review, we propose to explore the role of B cells in tumor immunity. First of all we define their dual role in promoting and inhibiting cancer progression depending on their phenotype. To continue, we describe the influence of different tumor microenvironment factors such as hypoxia on B cells functions and differentiation. Finally, the role of B cells in response to therapy and as potential target is examined. In accordance with the importance of B cells in immunooncology, we conclude that more studies are required to throw light on the precise role of B cells in the tumor microenvironment in order to have a better understanding of their functions, and to design new strategies that efficiently target these cells by immunotherapy.

Original languageEnglish
Article number449
JournalCells
Volume8
Issue number5
DOIs
Publication statusPublished - 13 May 2019

Keywords

  • B lymphocytes
  • Breg
  • Immunotherapy
  • Tumor immunity
  • Tumor microenvironment

Fingerprint

Dive into the research topics of 'The B-side of cancer immunity: The underrated tune'. Together they form a unique fingerprint.

Cite this