The association of factor V G1961A (Factor V Leiden), prothrombin G20210A, MTHFR C677T and pai-1 4G/5G polymorphisms with recurrent pregnancy loss in Bosnian women

Amela Jusić*, Devleta Balić, Aldijana Avdić, Maja Pođanin, Adem Balić

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Aim To investigate association of factor V Leiden, prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Bosnian women. Methods A total of 60 women with two or more consecutive miscarriages before 20 weeks of gestation with the same partners and without history of known causes or recurrent pregnancy loss were included. A control group included 80 healthy women who had one or more successful pregnancies without history of any complication which could be associated with miscarriages. Genoty-ping of factor V Leiden, prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms were performed by polymerase chain reaction/restriction fragments length polymorphism method (PCR/RFLP). Results Both factor V Leiden and MTHFR C677T polymorphisms were significantly associated with recurrent pregnancy loss (RPL) in Bosnian women while prothrombin G20210A and PAI-1 4G/5G polymorphisms did not show strongly significant association. Conclusion The presence of thrombophilic polymorphisms may predispose women to recurrent pregnancy loss. Future investigation should be addressed in order to find when carriers of those mutations, polymorphisms should be treated with anticoagulant therapy.

Original languageEnglish
Pages (from-to)158-163
Number of pages6
JournalMedicinski Glasnik
Volume15
Issue number2
DOIs
Publication statusPublished - Aug 2018
Externally publishedYes

Keywords

  • Gene polymorphisms
  • Habitual abortions
  • Thrombophilia

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