The α1-antichymotrypsin A-allele in German Parkinson disease patients

E. M. Grasbon-Frodl; R. Egensperger; S. Kösel; R. Krüger; O. Riess; P. Mehraein; M. B. Graeber

doi:10.1007/s007020050193

The α₁-antichymotrypsin A-allele in German Parkinson disease patients

E. M. Grasbon-Frodl, R. Egensperger, S. Kösel, R. Krüger, O. Riess, P. Mehraein, M. B. Graeber^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Abstract

An increased frequency of the A-allele of the α₁-antichymotrypsin (ACT) gene has been recently described in Japanese patients suffering from Parkinson disease (PD). In the present study, we have analyzed 62 German PD patients with regard to their ACT and APOE genotypes and compared them to 53 controls without clinical or pathological evidence of neurodegenerative disease. The A-allele frequency was 47% in PD patients compared to 54% in control cases excluding ACT as a major susceptibility factor for PD in the Caucasian population. Yet, ACT-A allele frequencies were significantly different (p < 0.001) between Japanese and German controls. Therefore, although our data do not suggest that the α₁-ACT polymorphism is a significant risk factor for the development of PD, a consideration of differences in genetic background seems warranted when evaluating susceptibility factors for neurodegenerative disease.

Original language	English
Pages (from-to)	729-736
Number of pages	8
Journal	Journal of Neural Transmission
Volume	106
Issue number	7-8
DOIs	https://doi.org/10.1007/s007020050193
Publication status	Published - 1999
Externally published	Yes

Keywords

Alzheimer disease
Apolipoprotein E
Genetics
Neurodegeneration
Susceptibility allele

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10.1007/s007020050193

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title = "The α1-antichymotrypsin A-allele in German Parkinson disease patients",

abstract = "An increased frequency of the A-allele of the α1-antichymotrypsin (ACT) gene has been recently described in Japanese patients suffering from Parkinson disease (PD). In the present study, we have analyzed 62 German PD patients with regard to their ACT and APOE genotypes and compared them to 53 controls without clinical or pathological evidence of neurodegenerative disease. The A-allele frequency was 47% in PD patients compared to 54% in control cases excluding ACT as a major susceptibility factor for PD in the Caucasian population. Yet, ACT-A allele frequencies were significantly different (p < 0.001) between Japanese and German controls. Therefore, although our data do not suggest that the α1-ACT polymorphism is a significant risk factor for the development of PD, a consideration of differences in genetic background seems warranted when evaluating susceptibility factors for neurodegenerative disease.",

keywords = "Alzheimer disease, Apolipoprotein E, Genetics, Neurodegeneration, Susceptibility allele",

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T1 - The α1-antichymotrypsin A-allele in German Parkinson disease patients

AU - Grasbon-Frodl, E. M.

AU - Egensperger, R.

AU - Kösel, S.

AU - Krüger, R.

AU - Riess, O.

AU - Mehraein, P.

AU - Graeber, M. B.

PY - 1999

Y1 - 1999

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AB - An increased frequency of the A-allele of the α1-antichymotrypsin (ACT) gene has been recently described in Japanese patients suffering from Parkinson disease (PD). In the present study, we have analyzed 62 German PD patients with regard to their ACT and APOE genotypes and compared them to 53 controls without clinical or pathological evidence of neurodegenerative disease. The A-allele frequency was 47% in PD patients compared to 54% in control cases excluding ACT as a major susceptibility factor for PD in the Caucasian population. Yet, ACT-A allele frequencies were significantly different (p < 0.001) between Japanese and German controls. Therefore, although our data do not suggest that the α1-ACT polymorphism is a significant risk factor for the development of PD, a consideration of differences in genetic background seems warranted when evaluating susceptibility factors for neurodegenerative disease.

KW - Alzheimer disease

KW - Apolipoprotein E

KW - Genetics

KW - Neurodegeneration

KW - Susceptibility allele

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The α₁-antichymotrypsin A-allele in German Parkinson disease patients

Abstract

Keywords

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