The α1-antichymotrypsin A-allele in German Parkinson disease patients

E. M. Grasbon-Frodl, R. Egensperger, S. Kösel, R. Krüger, O. Riess, P. Mehraein, M. B. Graeber*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)


An increased frequency of the A-allele of the α1-antichymotrypsin (ACT) gene has been recently described in Japanese patients suffering from Parkinson disease (PD). In the present study, we have analyzed 62 German PD patients with regard to their ACT and APOE genotypes and compared them to 53 controls without clinical or pathological evidence of neurodegenerative disease. The A-allele frequency was 47% in PD patients compared to 54% in control cases excluding ACT as a major susceptibility factor for PD in the Caucasian population. Yet, ACT-A allele frequencies were significantly different (p < 0.001) between Japanese and German controls. Therefore, although our data do not suggest that the α1-ACT polymorphism is a significant risk factor for the development of PD, a consideration of differences in genetic background seems warranted when evaluating susceptibility factors for neurodegenerative disease.

Original languageEnglish
Pages (from-to)729-736
Number of pages8
JournalJournal of Neural Transmission
Issue number7-8
Publication statusPublished - 1999
Externally publishedYes


  • Alzheimer disease
  • Apolipoprotein E
  • Genetics
  • Neurodegeneration
  • Susceptibility allele


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