Testing for baseline balance in clinical trials

Stephen Senn*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

341 Citations (Scopus)

Abstract

Once the data from a clinical trial are available for analysis it is common practice to carry out ‘tests of baseline homogeneity’ on prognostic covariates before proceeding to analyse the effects of treatment on outcome variables. It is argued that this practice is philosophically unsound, of no practical value and potentially misleading. Instead it is recommended that prognostic variables be identified in the trial‐plan and fitted in an analysis of covariance regardless of their baseline distribution (statistical significance).

Original languageEnglish
Pages (from-to)1715-1726
Number of pages12
JournalStatistics in Medicine
Volume13
Issue number17
DOIs
Publication statusPublished - 15 Sept 1994
Externally publishedYes

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