TY - JOUR
T1 - Tea consumption and incidence of type 2 diabetes in Europe
T2 - The EPIC-interact case-cohort study
AU - van Woudenbergh, Geertruida J.
AU - Kuijsten, Anneleen
AU - Drogan, Dagmar
AU - van der A, Daphne L.
AU - Romaguera, Dora
AU - Ardanaz, Eva
AU - Amiano, Pilar
AU - Barricarte, Aurelio
AU - Beulens, Joline W.J.
AU - Boeing, Heiner
AU - Bueno-de-Mesquita, H. Bas
AU - Dahm, Christina C.
AU - Chirlaque, M. Doleres
AU - Clavel, Francoise
AU - Crowe, Francesca L.
AU - Eomois, Piia Piret
AU - Fagherazzi, Guy
AU - Franks, Paul W.
AU - Halkjær, Jytte
AU - Khaw, Kay T.
AU - Masala, Giovanna
AU - Mattiello, Amalia
AU - Nilsson, Peter
AU - Overvad, Kim
AU - Quirós, J. Ramón
AU - Rolandsson, Olov
AU - Romieu, Isabelle
AU - Sacerdote, Carlotta
AU - Sánchez, María José
AU - Schulze, Matthias B.
AU - Slimani, Nadia
AU - Sluijs, Ivonne
AU - Spijkerman, Annemieke M.W.
AU - Tagliabue, Giovanna
AU - Teucher, Birgit
AU - Tjønneland, Anne
AU - Tumino, Rosario
AU - Forouhi, Nita G.
AU - Sharp, Stephen
AU - Langenberg, Claudia
AU - Feskens, Edith J.M.
AU - Riboli, Elio
AU - Wareham, Nicholas J.
PY - 2012/5/30
Y1 - 2012/5/30
N2 - Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. Methodology/Principal Findings: The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-<1, 1-<4, ≥4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95%CI 0.71, 1.00] when participants who drank ≥4 cups of tea per day were compared with non-drinkers (plinear trend = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-<4 cups/day (HR = 0.93 [95%CI 0.81, 1.05]). Spline regression did not suggest a non-linear association (pnon-linearity = 0.20). Conclusions/Significance: A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.
AB - Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. Methodology/Principal Findings: The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-<1, 1-<4, ≥4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95%CI 0.71, 1.00] when participants who drank ≥4 cups of tea per day were compared with non-drinkers (plinear trend = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-<4 cups/day (HR = 0.93 [95%CI 0.81, 1.05]). Spline regression did not suggest a non-linear association (pnon-linearity = 0.20). Conclusions/Significance: A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.
UR - http://www.scopus.com/inward/record.url?scp=84861633798&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0036910
DO - 10.1371/journal.pone.0036910
M3 - Article
C2 - 22666334
AN - SCOPUS:84861633798
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 5
M1 - e36910
ER -