Targeting MTHFD1 and MTHFD2 as cancer treatment

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 100%
• Small Molecule 50%
• Enzyme 50%
• Carbon Metabolism 50%
• DNA Repair 50%
• DNA Damage 50%
• Myeloid 50%
• 10-Formyltetrahydrofolate 50%
• Cell Death 50%
• Thymidine Monophosphate 50%
• Non-Homologous End Joining 25%
• Nucleotide Metabolism 25%
• DNA Damage Response 25%
• Mitochondrion 25%
• BRCA1 25%
• DNA Synthesis 25%
• Poly ADP Ribose Polymerase 25%
• Programmed Cell Death 25%
• Uracil 25%
• Double-Strand DNA Break 25%
• phosphorylation 25%

Keyphrases

• Cancer Treatment 100%
• MTHFD2 100%
• MTHFD1 100%
• Mechanism of Action 26%
• Cancer Cells 20%
• In Cancer 20%
• Cell Death 13%
• Therapeutic Potential 13%
• DNA Damage 13%
• DNA Repair 13%
• Small Molecules 13%
• One-carbon Metabolism 13%
• Thymidylate 13%
• 10-formyltetrahydrofolate 13%
• Nuclear Role 13%
• Putative Drug Targets 6%
• Breast Cancer 6%
• Acute Myeloid Leukemia 6%
• Leukemia Cells 6%
• Expression Profile 6%
• Ionizing Radiation 6%
• Potent Inhibitor 6%
• Phosphorylation 6%
• Mitochondria 6%
• Metabolic Activity 6%
• Apoptosis Induction 6%
• Irradiation 6%
• Double-strand Break Repair 6%
• DNA Replication 6%
• Acute Myeloid Leukemia Cells 6%
• DNA Double-strand Break Repair 6%
• DNA Damage Response 6%
• Formate 6%
• Nuclear Localization 6%
• Formate Overflow 6%
• DNA-dependent Protein Kinase (DNA-PK) 6%
• Colorectal Cancer Cells 6%
• Nuclear Function 6%
• Defective DNA 6%
• Metabolic Rewiring 6%
• Replication Stress 6%
• Misincorporation 6%
• Uracil 6%
• DNA End Resection 6%
• HR Repair 6%
• NHEJ Repair 6%
• Mouse Xenograft Model 6%
• Nucleotide Synthesis 6%
• One-carbon Pathway 6%
• Repair Mechanism 6%
• Rapid Proliferation 6%
• PARP Inhibitors (PARPi) 6%
• New Inhibitors 6%