Targeted proteomics on its way to discovery

Marta L Mendes, Gunnar Dittmar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

For a long time, targeted and discovery proteomics covered different corners of the detection spectrum, with targeted proteomics focused on small target sets. This changed with the recent advances in highly multiplexed analysis. While discovery proteomics still pushes higher numbers of identified and quantified proteins, the advances in targeted proteomics rose to cover large parts of less complex proteomes or proteomes with low protein detection counts due to dynamic range restrictions, like the blood proteome. These new developments will impact, especially on the field of biomarker discovery and the possibility of using targeted proteomics for diagnostic purposes.

Original languageEnglish
Article numbere2100330
JournalProteomics
Volume22
Issue number15-16
Early online date18 Jul 2022
DOIs
Publication statusPublished - Aug 2022

Keywords

  • DIA
  • multiplexing
  • PRM
  • proteomics
  • targeted proteomics

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