Synthesis and pharmacological activities of 7-azaindole derivatives

Nousheen Mushtaq*, Z. S. Saify, Fozia Noor, Shamoona Takween, Shamim Akhtar, Muhammad Arif, Khalid M. Khan

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)


As a part of our program to discover novel analogues of 7-azaindole (1H-Pyrrolo[2,3-b] pyridine) having useful biological activities, some derivatives have been synthesized and evaluated for their analgesic and hypotensive activity. Compounds evaluated by thermal stimuli (tail immersion method) at the dose of 50 mg/kg of body weight revealed significant analgesic activity. Pethidine was used as reference drug. Same compounds tested at the dose of 75mg/kg of body weight showed toxicity. Compounds tested for their effect on blood pressure in normotensive rat produced slight fall in blood pressure.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalPakistan Journal of Pharmaceutical Sciences
Issue number1
Publication statusPublished - 2008
Externally publishedYes


  • 7-azaindole
  • Analgesic
  • Hypotensive activity
  • Synthesis


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