Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases

Sergio Valente, Emilie Bana, Elodie Viry, Denyse Bagrel, Gilbert Kirsch*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)


The cell division cycle 25 (Cdc25) family of proteins are dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. Overexpression of Cdc25 proteins has been reported in a wide variety of cancers; their inhibition may thus represent a novel approach for the development of anticancer therapeutics. Herein we report new coumarin-based scaffolds endowed with a selective inhibition against Cdc25A and Cdc25C, being 6a and 6d the most efficient inhibitors and worthy of further investigation as anticancer agents.

Original languageEnglish
Pages (from-to)5827-5830
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
Publication statusPublished - 1 Oct 2010
Externally publishedYes


  • Cdc25 phosphatases
  • Chalcones
  • Coumarins
  • Heck coupling


Dive into the research topics of 'Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases'. Together they form a unique fingerprint.

Cite this