Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Eva M. Navarrete-Muñoz; Petra A. Wark; Dora Romaguera; Nirmala Bhoo-Pathy; Dominique Michaud; Esther Molina-Montes; Anne Tjønneland; Anja Olsen; Kim Overvad; Marie Christine Boutron-Ruault; Françoise Clavel-Chapelon; Guy Fagherazzi; Verena A. Katzke; Tilman Kühn; Annika Steffen; Antonia Trichopoulou; Eleni Klinaki; Eleni Maria Papatesta; Giovanna Masala; Vittorio Krogh; Rosario Tumino; Alessio Naccarati; Amalia Mattiello; Petra H. Peeters; Charlotta Rylander; Christine L. Parr; Guri Skeie; Elisabete Weiderpass; J. Ramón Quirós; Eric J. Duell; Miren Dorronsoro; José María Huerta; Eva Ardanaz; Nick Wareham; Kay Tee Khaw; Ruth C. Travis; Tim Key; Magdalena Stepien; Heinz Freisling; Elio Riboli; H. Bas Bueno-De-mesquita

doi:10.3945/ajcn.116.130963

Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Eva M. Navarrete-Muñoz, Petra A. Wark, Dora Romaguera^*, Nirmala Bhoo-Pathy, Dominique Michaud, Esther Molina-Montes, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Guy Fagherazzi, Verena A. Katzke, Tilman Kühn, Annika Steffen, Antonia Trichopoulou, Eleni Klinaki, Eleni Maria Papatesta, Giovanna Masala, Vittorio KroghRosario Tumino, Alessio Naccarati, Amalia Mattiello, Petra H. Peeters, Charlotta Rylander, Christine L. Parr, Guri Skeie, Elisabete Weiderpass, J. Ramón Quirós, Eric J. Duell, Miren Dorronsoro, José María Huerta, Eva Ardanaz, Nick Wareham, Kay Tee Khaw, Ruth C. Travis, Tim Key, Magdalena Stepien, Heinz Freisling, Elio Riboli, H. Bas Bueno-De-mesquita

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

33 Citations (Scopus)

Abstract

Background: The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well. Objective: We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk. Design: The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baselinenot associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake. Conclusions: Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results. Am J Clin Nutr 2016;104:760-8.

Original language	English
Pages (from-to)	760-768
Number of pages	9
Journal	American Journal of Clinical Nutrition
Volume	104
Issue number	3
DOIs	https://doi.org/10.3945/ajcn.116.130963
Publication status	Published - 1 Sept 2016
Externally published	Yes

Keywords

Epidemiology
Juice and nectar
Pancreatic cancer
Prevention
Risk factors
Soft drinks
Sugary drinks
Sweet beverages

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10.3945/ajcn.116.130963

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Navarrete-Muñoz, E. M., Wark, P. A., Romaguera, D., Bhoo-Pathy, N., Michaud, D., Molina-Montes, E., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, G., Katzke, V. A., Kühn, T., Steffen, A., Trichopoulou, A., Klinaki, E., Papatesta, E. M., Masala, G., ... Bueno-De-mesquita, H. B. (2016). Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). American Journal of Clinical Nutrition, 104(3), 760-768. https://doi.org/10.3945/ajcn.116.130963

@article{e24f7a53f7e945daa975f70bc7e6e48c,

title = "Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)",

abstract = "Background: The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well. Objective: We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk. Design: The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baselinenot associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake. Conclusions: Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results. Am J Clin Nutr 2016;104:760-8.",

keywords = "Epidemiology, Juice and nectar, Pancreatic cancer, Prevention, Risk factors, Soft drinks, Sugary drinks, Sweet beverages",

author = "Navarrete-Mu{\~n}oz, {Eva M.} and Wark, {Petra A.} and Dora Romaguera and Nirmala Bhoo-Pathy and Dominique Michaud and Esther Molina-Montes and Anne Tj{\o}nneland and Anja Olsen and Kim Overvad and Boutron-Ruault, {Marie Christine} and Fran{\c c}oise Clavel-Chapelon and Guy Fagherazzi and Katzke, {Verena A.} and Tilman K{\"u}hn and Annika Steffen and Antonia Trichopoulou and Eleni Klinaki and Papatesta, {Eleni Maria} and Giovanna Masala and Vittorio Krogh and Rosario Tumino and Alessio Naccarati and Amalia Mattiello and Peeters, {Petra H.} and Charlotta Rylander and Parr, {Christine L.} and Guri Skeie and Elisabete Weiderpass and Quir{\'o}s, {J. Ram{\'o}n} and Duell, {Eric J.} and Miren Dorronsoro and Huerta, {Jos{\'e} Mar{\'i}a} and Eva Ardanaz and Nick Wareham and Khaw, {Kay Tee} and Travis, {Ruth C.} and Tim Key and Magdalena Stepien and Heinz Freisling and Elio Riboli and Bueno-De-mesquita, {H. Bas}",

note = "Publisher Copyright: {\textcopyright} 2016 American Society for Nutrition.",

year = "2016",

month = sep,

day = "1",

doi = "10.3945/ajcn.116.130963",

language = "English",

volume = "104",

pages = "760--768",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "American Society for Nutrition",

number = "3",

}

Navarrete-Muñoz, EM, Wark, PA, Romaguera, D, Bhoo-Pathy, N, Michaud, D, Molina-Montes, E, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, MC, Clavel-Chapelon, F, Fagherazzi, G, Katzke, VA, Kühn, T, Steffen, A, Trichopoulou, A, Klinaki, E, Papatesta, EM, Masala, G, Krogh, V, Tumino, R, Naccarati, A, Mattiello, A, Peeters, PH, Rylander, C, Parr, CL, Skeie, G, Weiderpass, E, Quirós, JR, Duell, EJ, Dorronsoro, M, Huerta, JM, Ardanaz, E, Wareham, N, Khaw, KT, Travis, RC, Key, T, Stepien, M, Freisling, H, Riboli, E & Bueno-De-mesquita, HB 2016, 'Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)', American Journal of Clinical Nutrition, vol. 104, no. 3, pp. 760-768. https://doi.org/10.3945/ajcn.116.130963

TY - JOUR

T1 - Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Navarrete-Muñoz, Eva M.

AU - Wark, Petra A.

AU - Romaguera, Dora

AU - Bhoo-Pathy, Nirmala

AU - Michaud, Dominique

AU - Molina-Montes, Esther

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Fagherazzi, Guy

AU - Katzke, Verena A.

AU - Kühn, Tilman

AU - Steffen, Annika

AU - Trichopoulou, Antonia

AU - Klinaki, Eleni

AU - Papatesta, Eleni Maria

AU - Masala, Giovanna

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Naccarati, Alessio

AU - Mattiello, Amalia

AU - Peeters, Petra H.

AU - Rylander, Charlotta

AU - Parr, Christine L.

AU - Skeie, Guri

AU - Weiderpass, Elisabete

AU - Quirós, J. Ramón

AU - Duell, Eric J.

AU - Dorronsoro, Miren

AU - Huerta, José María

AU - Ardanaz, Eva

AU - Wareham, Nick

AU - Khaw, Kay Tee

AU - Travis, Ruth C.

AU - Key, Tim

AU - Stepien, Magdalena

AU - Freisling, Heinz

AU - Riboli, Elio

AU - Bueno-De-mesquita, H. Bas

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background: The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well. Objective: We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk. Design: The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baselinenot associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake. Conclusions: Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results. Am J Clin Nutr 2016;104:760-8.

AB - Background: The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well. Objective: We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk. Design: The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baselinenot associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake. Conclusions: Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results. Am J Clin Nutr 2016;104:760-8.

KW - Epidemiology

KW - Juice and nectar

KW - Pancreatic cancer

KW - Prevention

KW - Risk factors

KW - Soft drinks

KW - Sugary drinks

KW - Sweet beverages

UR - http://www.scopus.com/inward/record.url?scp=84985993260&partnerID=8YFLogxK

U2 - 10.3945/ajcn.116.130963

DO - 10.3945/ajcn.116.130963

M3 - Article

C2 - 27510540

AN - SCOPUS:84985993260

SN - 0002-9165

VL - 104

SP - 760

EP - 768

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 3

ER -

Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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Keywords

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