TY - JOUR
T1 - Susceptibility to Vaccine-Preventable Diseases in Four Districts of Xaysomboun Province, Lao People’s Democratic Republic
AU - Virachith, Siriphone
AU - Lao, Mapor
AU - Inthepphavong, Magnoula
AU - Inthalath, Saythong
AU - Hübschen, Judith M.
AU - Kounnavong, Sengchanh
AU - Sayasone, Somphou
AU - Black, Antony P.
N1 - Funding Information:
This work was supported by ?PaReCIDs II? grant from the Luxembourg Ministry of European and Foreign Affairs and Lao Tropical and Public Health Institute?s Education Fund.
Funding Information:
Funding: This work was supported by “PaReCIDs II” grant from the Luxembourg Ministry of European and Foreign Affairs and Lao Tropical and Public Health Institute’s Education Fund.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3/17
Y1 - 2022/3/17
N2 - Xaysomboun province has some of the lowest health indicators in Lao People’s Democratic Republic (PDR). This cross-sectional study aimed to determine the vaccination, susceptibility and exposure status of the population to hepatitis B virus (HBV), measles, rubella, and tetanus. Participants aged 5 years and older were randomly selected from four districts. From each enrolled participant, demographic data and 5 mL of blood sample were taken. HBV surface antigen (HBsAg) and antibodies against HBV, measles, rubella, and tetanus were detected by ELISA. A total of 363 participants (age 5 to 80 years) were included. HBV exposure, as determined by anti-HBV core (anti-HBc) antibodies, was 56.2% overall, and was significantly higher among those aged ≥ 21 years (78.1%). HBsAg was detected in 9.4% overall and increased to 20% in ages 31–40 years. Only 13.8% of participants had serology indicative of vaccination (anti-HBs positive, anti-HBc negative). Sero-protection against measles was 74.6% overall but only 41.7% in children aged 5–10 years. Anti-ru-bella IgG was 94.2% overall and high in all age groups. Tetanus seroprevalence was only 47.4% overall but significantly higher in females aged 31–40 (75.6%). We suggest strengthening of routine and booster HBV, measles, and tetanus vaccine coverage in Xaysomboun province.
AB - Xaysomboun province has some of the lowest health indicators in Lao People’s Democratic Republic (PDR). This cross-sectional study aimed to determine the vaccination, susceptibility and exposure status of the population to hepatitis B virus (HBV), measles, rubella, and tetanus. Participants aged 5 years and older were randomly selected from four districts. From each enrolled participant, demographic data and 5 mL of blood sample were taken. HBV surface antigen (HBsAg) and antibodies against HBV, measles, rubella, and tetanus were detected by ELISA. A total of 363 participants (age 5 to 80 years) were included. HBV exposure, as determined by anti-HBV core (anti-HBc) antibodies, was 56.2% overall, and was significantly higher among those aged ≥ 21 years (78.1%). HBsAg was detected in 9.4% overall and increased to 20% in ages 31–40 years. Only 13.8% of participants had serology indicative of vaccination (anti-HBs positive, anti-HBc negative). Sero-protection against measles was 74.6% overall but only 41.7% in children aged 5–10 years. Anti-ru-bella IgG was 94.2% overall and high in all age groups. Tetanus seroprevalence was only 47.4% overall but significantly higher in females aged 31–40 (75.6%). We suggest strengthening of routine and booster HBV, measles, and tetanus vaccine coverage in Xaysomboun province.
KW - antibodies
KW - diphtheria
KW - hepatitis B
KW - Laos
KW - measles
KW - rubella
KW - tetanus
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=85127453906&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/35335095
U2 - 10.3390/vaccines10030463
DO - 10.3390/vaccines10030463
M3 - Article
C2 - 35335095
AN - SCOPUS:85127453906
SN - 2076-393X
VL - 10
JO - Vaccines
JF - Vaccines
IS - 3
M1 - 463
ER -