[¹⁴C] Milk, urine and faeces excretion kinetics in lactating goats after an oral administration of [¹⁴C]polycyclic aromatic hydrocarbons

The aim of this work was to characterize phenanthrene, pyrene, benzo(a)pyrene and TCDD transfer to milk, urine and faeces in lactating goats after a single oral ingestion (2.5 10⁶ Bq) of [¹⁴C]phenanthrene, [¹⁴C]pyrene, [¹⁴C]benzo[a]pyrene or [¹⁴C]2,3,7,8-TCDD. Seven hours after [¹⁴C] PAHs oral ingestion, a radioactivity peak was detected in plasma for all compounds studied. Regarding excretion routes, three specific types of behaviour were noticed: 2,3,7,8-TCDD was mainly excreted in milk (7.8%) and a large part of radioactivity ingested remained in the organism (71.2%). Phenanthrene and pyrene presented a similar behaviour, with a low milk transfer (1.6% and 1.9%, respectively) and a high excretion through urine (40.4% and 11.4%, respectively) suggesting their metabolization. Benzo[a]pyrene was poorly absorbed (88% of the ingested part of this compound was detected in faeces) and radioactivity due to benzo[a]pyrene was not significantly detected in milk (0.2%).