TY - JOUR
T1 - [14C] Milk, urine and faeces excretion kinetics in lactating goats after an oral administration of [14C]polycyclic aromatic hydrocarbons
AU - Grova, Nathalie
AU - Feidt, Cyril
AU - Laurent, Claire
AU - Rychen, Guido
N1 - Funding Information:
We thank A.D.E.M.E (Agence De l'Environnement et Maı̂trise de l'Energie), the “Region Lorraine”, the French Ministry of Fisheries and Agriculture and of Research and the French Ministry of Education for financial support.
PY - 2002
Y1 - 2002
N2 - The aim of this work was to characterize phenanthrene, pyrene, benzo(a)pyrene and TCDD transfer to milk, urine and faeces in lactating goats after a single oral ingestion (2.5 106 Bq) of [14C]phenanthrene, [14C]pyrene, [14C]benzo[a]pyrene or [14C]2,3,7,8-TCDD. Seven hours after [14C] PAHs oral ingestion, a radioactivity peak was detected in plasma for all compounds studied. Regarding excretion routes, three specific types of behaviour were noticed: 2,3,7,8-TCDD was mainly excreted in milk (7.8%) and a large part of radioactivity ingested remained in the organism (71.2%). Phenanthrene and pyrene presented a similar behaviour, with a low milk transfer (1.6% and 1.9%, respectively) and a high excretion through urine (40.4% and 11.4%, respectively) suggesting their metabolization. Benzo[a]pyrene was poorly absorbed (88% of the ingested part of this compound was detected in faeces) and radioactivity due to benzo[a]pyrene was not significantly detected in milk (0.2%).
AB - The aim of this work was to characterize phenanthrene, pyrene, benzo(a)pyrene and TCDD transfer to milk, urine and faeces in lactating goats after a single oral ingestion (2.5 106 Bq) of [14C]phenanthrene, [14C]pyrene, [14C]benzo[a]pyrene or [14C]2,3,7,8-TCDD. Seven hours after [14C] PAHs oral ingestion, a radioactivity peak was detected in plasma for all compounds studied. Regarding excretion routes, three specific types of behaviour were noticed: 2,3,7,8-TCDD was mainly excreted in milk (7.8%) and a large part of radioactivity ingested remained in the organism (71.2%). Phenanthrene and pyrene presented a similar behaviour, with a low milk transfer (1.6% and 1.9%, respectively) and a high excretion through urine (40.4% and 11.4%, respectively) suggesting their metabolization. Benzo[a]pyrene was poorly absorbed (88% of the ingested part of this compound was detected in faeces) and radioactivity due to benzo[a]pyrene was not significantly detected in milk (0.2%).
KW - Faeces
KW - Goat
KW - Milk
KW - PAHs
KW - Plasma
KW - Transfer
KW - Urine
UR - http://www.scopus.com/inward/record.url?scp=0036989658&partnerID=8YFLogxK
U2 - 10.1016/S0958-6946(02)00126-7
DO - 10.1016/S0958-6946(02)00126-7
M3 - Article
AN - SCOPUS:0036989658
SN - 0958-6946
VL - 12
SP - 1025
EP - 1031
JO - International Dairy Journal
JF - International Dairy Journal
IS - 12
ER -