[14C] Milk, urine and faeces excretion kinetics in lactating goats after an oral administration of [14C]polycyclic aromatic hydrocarbons

Nathalie Grova, Cyril Feidt, Claire Laurent, Guido Rychen*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Abstract

The aim of this work was to characterize phenanthrene, pyrene, benzo(a)pyrene and TCDD transfer to milk, urine and faeces in lactating goats after a single oral ingestion (2.5 106 Bq) of [14C]phenanthrene, [14C]pyrene, [14C]benzo[a]pyrene or [14C]2,3,7,8-TCDD. Seven hours after [14C] PAHs oral ingestion, a radioactivity peak was detected in plasma for all compounds studied. Regarding excretion routes, three specific types of behaviour were noticed: 2,3,7,8-TCDD was mainly excreted in milk (7.8%) and a large part of radioactivity ingested remained in the organism (71.2%). Phenanthrene and pyrene presented a similar behaviour, with a low milk transfer (1.6% and 1.9%, respectively) and a high excretion through urine (40.4% and 11.4%, respectively) suggesting their metabolization. Benzo[a]pyrene was poorly absorbed (88% of the ingested part of this compound was detected in faeces) and radioactivity due to benzo[a]pyrene was not significantly detected in milk (0.2%).

Original languageEnglish
Pages (from-to)1025-1031
Number of pages7
JournalInternational Dairy Journal
Volume12
Issue number12
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Faeces
  • Goat
  • Milk
  • PAHs
  • Plasma
  • Transfer
  • Urine

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