TY - JOUR
T1 - [11C]PIB binding in Parkinson's disease dementia
AU - Maetzler, Walter
AU - Reimold, Matthias
AU - Liepelt, Inga
AU - Solbach, Christoph
AU - Leyhe, Thomas
AU - Schweitzer, Katherine
AU - Eschweiler, Gerhard W.
AU - Mittelbronn, Michel
AU - Gaenslen, Alexandra
AU - Uebele, Michael
AU - Reischl, Gerald
AU - Gasser, Thomas
AU - Machulla, Hans Jürgen
AU - Bares, Roland
AU - Berg, Daniela
PY - 2008/2/1
Y1 - 2008/2/1
N2 - [11C]PIB (11C-6-OH benzothiazole) reflects the regional distribution of amyloid (beta-sheeted proteins) in patients with Alzheimer's disease (AD). Proteinaceous inclusions in Parkinson's disease with dementia (PDD), so-called Lewy bodies, also consist of fibrillar, misfolded proteins, chiefly α-synuclein. To test whether PDD subjects show specific amyloid binding in vivo and whether this could reflect fibrillar α-synuclein accumulation, we investigated 10 PDD subjects with [11C]PIB-PET. Radioligand binding was compared to that in 11 control and 6 AD subjects. Furthermore, postmortem sections of 4 patients with Parkinson's disease (PD), therefrom 2 with dementia (PDD), and of 6 controls were stained with PIB to evaluate the histological distribution of the fluorescent ligand in the brainstem. In PET, only 2 PDD patients displayed increased PIB binding to cortical amyloid comparable to AD patients. The other 8 patients showed control-like cortical findings but elevated PIB binding in the pons and mesencephalon. Fluorescence microscopy showed PIB binding to Lewy bodies and neuromelanin in the substantia nigra of PD and PDD brainstem sections, but not in controls. These data suggest that PIB-PET can be used to further differentiate PDD with respect to cortical amyloid. Furthermore, we provide evidence that - in addition to nonspecific binding - PIB uptake in the brainstem may also reflect PDD related amyloid.
AB - [11C]PIB (11C-6-OH benzothiazole) reflects the regional distribution of amyloid (beta-sheeted proteins) in patients with Alzheimer's disease (AD). Proteinaceous inclusions in Parkinson's disease with dementia (PDD), so-called Lewy bodies, also consist of fibrillar, misfolded proteins, chiefly α-synuclein. To test whether PDD subjects show specific amyloid binding in vivo and whether this could reflect fibrillar α-synuclein accumulation, we investigated 10 PDD subjects with [11C]PIB-PET. Radioligand binding was compared to that in 11 control and 6 AD subjects. Furthermore, postmortem sections of 4 patients with Parkinson's disease (PD), therefrom 2 with dementia (PDD), and of 6 controls were stained with PIB to evaluate the histological distribution of the fluorescent ligand in the brainstem. In PET, only 2 PDD patients displayed increased PIB binding to cortical amyloid comparable to AD patients. The other 8 patients showed control-like cortical findings but elevated PIB binding in the pons and mesencephalon. Fluorescence microscopy showed PIB binding to Lewy bodies and neuromelanin in the substantia nigra of PD and PDD brainstem sections, but not in controls. These data suggest that PIB-PET can be used to further differentiate PDD with respect to cortical amyloid. Furthermore, we provide evidence that - in addition to nonspecific binding - PIB uptake in the brainstem may also reflect PDD related amyloid.
UR - http://www.scopus.com/inward/record.url?scp=37849039499&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2007.09.072
DO - 10.1016/j.neuroimage.2007.09.072
M3 - Article
C2 - 18035558
AN - SCOPUS:37849039499
SN - 1053-8119
VL - 39
SP - 1027
EP - 1033
JO - NeuroImage
JF - NeuroImage
IS - 3
ER -