Sugar- and artificially-sweetened soda consumption and subclinical atherosclerosis among Mexican women

Adrian Cortés-Valencia, Mariel Arvizu, Adriana Monge, Eduardo Ortiz-Panozo, Ruy López-Ridaura, Carlos Cantu-Brito, Jorge Chavarro, Andrés Catzin-Kuhlmann, Guy Fagherazzi, Elsa Yunes, Martin Lajous*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


Background and aims: Sugar-sweetened soda consumption is associated with most cardiometabolic risk factors. The role of artificially-sweetened beverages in cardiovascular disease (CVD) is inconclusive, but their consumption correlates with health impairment. Little is known about the contribution of soda consumption in subclinical stages of atherosclerosis. Therefore, we evaluated the relation between sugar- and artificially-sweetened soda consumption and carotid intima-media thickness (IMT) among Mexican women. Methods and results: We cross-sectionally evaluated 1093 women enrolled in the Mexican Teachers’ Cohort who were free of CVD, diabetes or cancer. Sugar- and artificially-sweetened soda consumption was estimated from a validated 140-item food frequency questionnaire in 2008 and all women underwent a carotid ultrasound assessment three years later. Participants were categorized into tertiles of soda consumption in servings/week. Subclinical atherosclerosis was defined as a mean left and/or right IMT ≥0.8 mm or the presence of plaque on either common carotid artery. In multivariable regression models, women in the highest tertile of sugar-sweetened soda consumption had 2.6% (95%CI: 0.8, 4.5) mean increased IMT, and had 2-fold the risk of carotid atherosclerosis (PR: 2.0, 95%CI: 1.3, 3.2) compared to those in the lowest tertile. In stratified analyses, older and postmenopausal women who consumed sugar-sweetened soda had an increased IMT and atherosclerosis risk. Artificially-sweetened soda consumption was not associated with IMT or carotid atherosclerosis. Conclusions: Sugar-sweetened soda consumption was associated with subclinical atherosclerosis among disease-free Mexican women. Public health strategies to decrease CVD should consider the impact of sugar-sweetened soda consumption, particularly in older women.

Original languageEnglish
Pages (from-to)2052-2060
Number of pages9
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number9
Publication statusPublished - Sept 2022
Externally publishedYes


  • Artificially-sweetened beverages
  • Cardiovascular disease
  • Carotid atherosclerosis
  • Intima-media thickness
  • Subclinical atherosclerosis
  • Sugar-sweetened beverages


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