Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses

Bishal Kumar Singh; Anna Koromyslova; Lisa Hefele; Clara Gürth; Grant S Hansman

doi:10.1128/JVI.03119-15

Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses

Bishal Kumar Singh, Anna Koromyslova, Lisa Hefele, Clara Gürth, Grant S Hansman

Research output: Contribution to journal › Article › Research › peer-review

35 Citations (Scopus)

Abstract

Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.

Original language	English
Pages (from-to)	2710-5
Number of pages	6
Journal	Journal of Virology
Volume	90
Issue number	5
DOIs	https://doi.org/10.1128/JVI.03119-15
Publication status	Published - 23 Dec 2015
Externally published	Yes

Keywords

Amino Acid Sequence
Amino Acid Substitution
Antibodies, Viral/immunology
Caliciviridae Infections/virology
Capsid/chemistry
Cross Reactions
Crystallography, X-Ray
Evolution, Molecular
Genetic Variation
Genotype
Humans
Models, Molecular
Molecular Sequence Data
Norovirus/chemistry
Protein Conformation

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title = "Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses",

abstract = "Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.",

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language = "English",

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T1 - Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses

AU - Singh, Bishal Kumar

AU - Koromyslova, Anna

AU - Hefele, Lisa

AU - Gürth, Clara

AU - Hansman, Grant S

PY - 2015/12/23

Y1 - 2015/12/23

N2 - Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.

AB - Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.

KW - Amino Acid Sequence

KW - Amino Acid Substitution

KW - Antibodies, Viral/immunology

KW - Caliciviridae Infections/virology

KW - Capsid/chemistry

KW - Cross Reactions

KW - Crystallography, X-Ray

KW - Evolution, Molecular

KW - Genetic Variation

KW - Genotype

KW - Humans

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Norovirus/chemistry

KW - Protein Conformation

UR - https://pubmed.ncbi.nlm.nih.gov/26699640

U2 - 10.1128/JVI.03119-15

DO - 10.1128/JVI.03119-15

M3 - Article

C2 - 26699640

SN - 0022-538X

VL - 90

SP - 2710

EP - 2715

JO - Journal of Virology

JF - Journal of Virology

IS - 5

ER -

Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses

Abstract

Keywords

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