Strepsesquitriol, a rearranged zizaane-type sesquiterpenoid from the deep-sea-derived actinomycete streptomyces sp. SCSIO 10355

Xian Wen Yang; Kun Peng; Zhong Liu; Gai Yun Zhang; Jie Li; Ning Wang; Andre Steinmetz; Yonghong Liu

doi:10.1021/np400923c

Strepsesquitriol, a rearranged zizaane-type sesquiterpenoid from the deep-sea-derived actinomycete streptomyces sp. SCSIO 10355

Xian Wen Yang
, Kun Peng
, Zhong Liu
, Gai Yun Zhang
, Jie Li
, Ning Wang
, Andre Steinmetz
, Yonghong Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

52 Citations (Scopus)

Abstract

Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S) -4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.2.1.0^1,5]undecane by NMR analysis and a theoretical optical rotation derived from quantum-chemical calculations. It showed moderate inhibitory activity against lipopolysaccharide-induced TNFα production in RAW264.7 macrophages.

Original language	English
Pages (from-to)	2360-2363
Number of pages	4
Journal	Journal of Natural Products
Volume	76
Issue number	12
DOIs	https://doi.org/10.1021/np400923c
Publication status	Published - 27 Dec 2013

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title = "Strepsesquitriol, a rearranged zizaane-type sesquiterpenoid from the deep-sea-derived actinomycete streptomyces sp. SCSIO 10355",

abstract = "Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S) -4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.2.1.01,5]undecane by NMR analysis and a theoretical optical rotation derived from quantum-chemical calculations. It showed moderate inhibitory activity against lipopolysaccharide-induced TNFα production in RAW264.7 macrophages.",

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year = "2013",

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doi = "10.1021/np400923c",

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T1 - Strepsesquitriol, a rearranged zizaane-type sesquiterpenoid from the deep-sea-derived actinomycete streptomyces sp. SCSIO 10355

AU - Yang, Xian Wen

AU - Peng, Kun

AU - Liu, Zhong

AU - Zhang, Gai Yun

AU - Li, Jie

AU - Wang, Ning

AU - Steinmetz, Andre

AU - Liu, Yonghong

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S) -4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.2.1.01,5]undecane by NMR analysis and a theoretical optical rotation derived from quantum-chemical calculations. It showed moderate inhibitory activity against lipopolysaccharide-induced TNFα production in RAW264.7 macrophages.

AB - Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S) -4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.2.1.01,5]undecane by NMR analysis and a theoretical optical rotation derived from quantum-chemical calculations. It showed moderate inhibitory activity against lipopolysaccharide-induced TNFα production in RAW264.7 macrophages.

UR - https://www.scopus.com/pages/publications/84891441349

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VL - 76

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 12

ER -

Strepsesquitriol, a rearranged zizaane-type sesquiterpenoid from the deep-sea-derived actinomycete streptomyces sp. SCSIO 10355

Abstract

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