Strepsesquitriol, a rearranged zizaane-type sesquiterpenoid from the deep-sea-derived actinomycete streptomyces sp. SCSIO 10355

Xian Wen Yang, Kun Peng, Zhong Liu, Gai Yun Zhang, Jie Li, Ning Wang, Andre Steinmetz, Yonghong Liu*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S) -4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.2.1.01,5]undecane by NMR analysis and a theoretical optical rotation derived from quantum-chemical calculations. It showed moderate inhibitory activity against lipopolysaccharide-induced TNFα production in RAW264.7 macrophages.

Original languageEnglish
Pages (from-to)2360-2363
Number of pages4
JournalJournal of Natural Products
Volume76
Issue number12
DOIs
Publication statusPublished - 27 Dec 2013

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