TY - JOUR
T1 - Strepsesquitriol, a rearranged zizaane-type sesquiterpenoid from the deep-sea-derived actinomycete streptomyces sp. SCSIO 10355
AU - Yang, Xian Wen
AU - Peng, Kun
AU - Liu, Zhong
AU - Zhang, Gai Yun
AU - Li, Jie
AU - Wang, Ning
AU - Steinmetz, Andre
AU - Liu, Yonghong
PY - 2013/12/27
Y1 - 2013/12/27
N2 - Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S) -4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.2.1.01,5]undecane by NMR analysis and a theoretical optical rotation derived from quantum-chemical calculations. It showed moderate inhibitory activity against lipopolysaccharide-induced TNFα production in RAW264.7 macrophages.
AB - Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S) -4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.2.1.01,5]undecane by NMR analysis and a theoretical optical rotation derived from quantum-chemical calculations. It showed moderate inhibitory activity against lipopolysaccharide-induced TNFα production in RAW264.7 macrophages.
UR - http://www.scopus.com/inward/record.url?scp=84891441349&partnerID=8YFLogxK
U2 - 10.1021/np400923c
DO - 10.1021/np400923c
M3 - Article
C2 - 24490634
AN - SCOPUS:84891441349
SN - 0163-3864
VL - 76
SP - 2360
EP - 2363
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 12
ER -