Statistical issues in short-term trials in asthma

Stephen John Senn*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)


Some current practices in designing and analyzing short-term trials in asthma are examined from a statistical point of view. The trials considered consist principally of crossover trials to examine dose response, onset of action, duration of action, and protective effects of treatments or bioequivalence. It is concluded that a proper appreciation of the way in which causality may be investigated in clinical trials would lead to an improvement in design and analysis of short-term trials in asthma.

Original languageEnglish
Pages (from-to)779-791
Number of pages13
JournalDrug Information Journal
Issue number3
Publication statusPublished - Jul 1993
Externally publishedYes


  • Baselines
  • Bioequivalence
  • Pharmacokinetics
  • Provocation
  • Repeated measures


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