Standard preanalytical coding for biospecimens; Defining the sample PREanalytical code

Fotini Betsou*, Sylvain Lehmann, Garry Ashton, Michael Barnes, Erica E. Benson, Domenico Coppola, Yvonne Desouza, James Eliason, Barbara Glazer, Fiorella Guadagni, Keith Harding, David J. Horsfall, Cynthia Kleeberger, Umberto Nanni, Anil Prasad, Kathi Shea, Amy Skubitz, Stella Somiari, Elaine Gunter

*Corresponding author for this work

Research output: Contribution to journalComment/debate

166 Citations (Scopus)


Background: Management and traceability of biospecimen preanalytical variations are necessary to provide effective and efficient interconnectivity and interoperability between Biobanks. Methods: Therefore, the International Society for Biological and Environmental Repositories Biospecimen Science Working Group developed a "Standard PREanalytical Code" (SPREC) that identifies the main preanalytical factors of clinical fluid and solid biospecimens and their simple derivatives. Results: The SPREC is easy to implement and can be integrated into Biobank quality management systems and databases. It can also be extended to nonhuman biorepository areas. Its flexibility allows integration of new novel technological developments in future versions. SPREC version 01 is presented in this article. Conclusions and Impact: Implementation of the SPREC is expected to facilitate and consolidate international multicenter biomarker identification research and biospecimen research in the clinical Biobank environment.

Original languageEnglish
Pages (from-to)1004-1011
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Issue number4
Publication statusPublished - Apr 2010


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