Spectrum of phenotypes and genotypes in Parkinson's disease

Olaf Riess*, Rejko Krüger, Jörg B. Schulz

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


The pathogenesis of Parkinsons disease (PD) is currently unknown. Environmental and genetic factors might contribute to the neurodegenerative process. Genetic mapping approaches in rare familial cases with autosomal recessive and autosomal dominant inheritance of PD suggest wide genetic heterogeneity of the disease. These gene loci in turn allow now a more specific clinical investigation of affected families to study the clinical heterogeneity of PD. The recent identification of mutations in three genes involved in protein degradation and aggregation in familial PD does now facilitate the deciphering of other genes involved in the pathogenesis of the disease.

Original languageEnglish
Pages (from-to)III15-III20
JournalJournal of Neurology, Supplement
Issue number3
Publication statusPublished - 2002
Externally publishedYes


  • Gene loci
  • Parkin
  • Parkinson's disease
  • UCHL1
  • α-synuclein


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