Space Radiobiology

Christine Elisabeth Hellweg; Carmen Arena; Sarah Baatout; Bjorn Baselet; Kristina Beblo-Vranesevic; Nicol Caplin; Richard Coos; Fabiana Da Pieve; Veronica De Micco; Nicolas Foray; Boris Hespeels; Anne Catherine Heuskin; Jessica Kronenberg; Tetyana Milojevic; Silvana Miranda; Victoria Moris; Sébastien Penninckx; Wilhelmina E. Radstake; Emil Rehnberg; Petra Rettberg; Kevin Tabury; Karine Van Doninck; Olivier Van Hoey; Guillaume Vogin; Yehoshua Socol

doi:10.1007/978-3-031-18810-7_10

Space Radiobiology

Christine Elisabeth Hellweg, Carmen Arena, Sarah Baatout, Bjorn Baselet, Kristina Beblo-Vranesevic, Nicol Caplin, Richard Coos, Fabiana Da Pieve, Veronica De Micco, Nicolas Foray, Boris Hespeels, Anne Catherine Heuskin, Jessica Kronenberg, Tetyana Milojevic, Silvana Miranda, Victoria Moris, Sébastien Penninckx, Wilhelmina E. Radstake, Emil Rehnberg, Petra RettbergKevin Tabury, Karine Van Doninck, Olivier Van Hoey, Guillaume Vogin, Yehoshua Socol^*

^*Corresponding author for this work

Tumor Immunotherapy and Microenvironment

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Abstract

The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history, characterization, and biological effects to the research that has been and is being conducted in the field. After a short introduction, you will learn the origin and characterization of the different types of space radiation and the use of mathematical models for the prediction of the radiation doses during different mission scenarios and estimate the biological risks due to this exposure. Following this, the acute, chronic, and late effects of radiation exposure in the human body are discussed before going into the detailed biomolecular changes affecting cells and tissues, and in which ways they differ from other types of radiation exposure. The next sections of this chapter are dedicated to the vast research that has been developed through the years concerning space radiation biology, from small animals to plant models and 3D cell cultures, the use of extremophiles in the study of radiation resistance mechanisms to the importance of ground-based irradiation facilities to simulate and study the space environment.

Original language	English
Title of host publication	Radiobiology Textbook
Publisher	Springer International Publishing
Pages	503-569
Number of pages	67
ISBN (Electronic)	9783031188107
ISBN (Print)	9783031188091
DOIs	https://doi.org/10.1007/978-3-031-18810-7_10
Publication status	Published - 1 Jan 2023

Keywords

Cancer risk
Cataract
Chromosomal aberrations
Galactic cosmic rays (GCR)
Light flashes
Monte Carlo methods
Particle accelerators
Radiation belts
Solar particle events (SPE)

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10.1007/978-3-031-18810-7_10Licence: CC BY

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Hellweg, C. E., Arena, C., Baatout, S., Baselet, B., Beblo-Vranesevic, K., Caplin, N., Coos, R., Da Pieve, F., De Micco, V., Foray, N., Hespeels, B., Heuskin, A. C., Kronenberg, J., Milojevic, T., Miranda, S., Moris, V., Penninckx, S., Radstake, W. E., Rehnberg, E., ... Socol, Y. (2023). Space Radiobiology. In Radiobiology Textbook (pp. 503-569). Springer International Publishing. https://doi.org/10.1007/978-3-031-18810-7_10

@inbook{90423238c1a84a4794ef048293817a78,

title = "Space Radiobiology",

abstract = "The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history, characterization, and biological effects to the research that has been and is being conducted in the field. After a short introduction, you will learn the origin and characterization of the different types of space radiation and the use of mathematical models for the prediction of the radiation doses during different mission scenarios and estimate the biological risks due to this exposure. Following this, the acute, chronic, and late effects of radiation exposure in the human body are discussed before going into the detailed biomolecular changes affecting cells and tissues, and in which ways they differ from other types of radiation exposure. The next sections of this chapter are dedicated to the vast research that has been developed through the years concerning space radiation biology, from small animals to plant models and 3D cell cultures, the use of extremophiles in the study of radiation resistance mechanisms to the importance of ground-based irradiation facilities to simulate and study the space environment.",

keywords = "Cancer risk, Cataract, Chromosomal aberrations, Galactic cosmic rays (GCR), Light flashes, Monte Carlo methods, Particle accelerators, Radiation belts, Solar particle events (SPE)",

author = "Hellweg, {Christine Elisabeth} and Carmen Arena and Sarah Baatout and Bjorn Baselet and Kristina Beblo-Vranesevic and Nicol Caplin and Richard Coos and {Da Pieve}, Fabiana and {De Micco}, Veronica and Nicolas Foray and Boris Hespeels and Heuskin, {Anne Catherine} and Jessica Kronenberg and Tetyana Milojevic and Silvana Miranda and Victoria Moris and S{\'e}bastien Penninckx and Radstake, {Wilhelmina E.} and Emil Rehnberg and Petra Rettberg and Kevin Tabury and {Van Doninck}, Karine and {Van Hoey}, Olivier and Guillaume Vogin and Yehoshua Socol",

note = "Publisher Copyright: {\textcopyright} The Editor(s) (if applicable) and The Author(s) 2023.",

year = "2023",

month = jan,

day = "1",

doi = "10.1007/978-3-031-18810-7_10",

language = "English",

isbn = "9783031188091",

pages = "503--569",

booktitle = "Radiobiology Textbook",

publisher = "Springer International Publishing",

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Hellweg, CE, Arena, C, Baatout, S, Baselet, B, Beblo-Vranesevic, K, Caplin, N, Coos, R, Da Pieve, F, De Micco, V, Foray, N, Hespeels, B, Heuskin, AC, Kronenberg, J, Milojevic, T, Miranda, S, Moris, V, Penninckx, S, Radstake, WE, Rehnberg, E, Rettberg, P, Tabury, K, Van Doninck, K, Van Hoey, O, Vogin, G & Socol, Y 2023, Space Radiobiology. in Radiobiology Textbook. Springer International Publishing, pp. 503-569. https://doi.org/10.1007/978-3-031-18810-7_10

TY - CHAP

T1 - Space Radiobiology

AU - Hellweg, Christine Elisabeth

AU - Arena, Carmen

AU - Baatout, Sarah

AU - Baselet, Bjorn

AU - Beblo-Vranesevic, Kristina

AU - Caplin, Nicol

AU - Coos, Richard

AU - Da Pieve, Fabiana

AU - De Micco, Veronica

AU - Foray, Nicolas

AU - Hespeels, Boris

AU - Heuskin, Anne Catherine

AU - Kronenberg, Jessica

AU - Milojevic, Tetyana

AU - Miranda, Silvana

AU - Moris, Victoria

AU - Penninckx, Sébastien

AU - Radstake, Wilhelmina E.

AU - Rehnberg, Emil

AU - Rettberg, Petra

AU - Tabury, Kevin

AU - Van Doninck, Karine

AU - Van Hoey, Olivier

AU - Vogin, Guillaume

AU - Socol, Yehoshua

PY - 2023/1/1

Y1 - 2023/1/1

N2 - The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history, characterization, and biological effects to the research that has been and is being conducted in the field. After a short introduction, you will learn the origin and characterization of the different types of space radiation and the use of mathematical models for the prediction of the radiation doses during different mission scenarios and estimate the biological risks due to this exposure. Following this, the acute, chronic, and late effects of radiation exposure in the human body are discussed before going into the detailed biomolecular changes affecting cells and tissues, and in which ways they differ from other types of radiation exposure. The next sections of this chapter are dedicated to the vast research that has been developed through the years concerning space radiation biology, from small animals to plant models and 3D cell cultures, the use of extremophiles in the study of radiation resistance mechanisms to the importance of ground-based irradiation facilities to simulate and study the space environment.

AB - The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history, characterization, and biological effects to the research that has been and is being conducted in the field. After a short introduction, you will learn the origin and characterization of the different types of space radiation and the use of mathematical models for the prediction of the radiation doses during different mission scenarios and estimate the biological risks due to this exposure. Following this, the acute, chronic, and late effects of radiation exposure in the human body are discussed before going into the detailed biomolecular changes affecting cells and tissues, and in which ways they differ from other types of radiation exposure. The next sections of this chapter are dedicated to the vast research that has been developed through the years concerning space radiation biology, from small animals to plant models and 3D cell cultures, the use of extremophiles in the study of radiation resistance mechanisms to the importance of ground-based irradiation facilities to simulate and study the space environment.

KW - Cancer risk

KW - Cataract

KW - Chromosomal aberrations

KW - Galactic cosmic rays (GCR)

KW - Light flashes

KW - Monte Carlo methods

KW - Particle accelerators

KW - Radiation belts

KW - Solar particle events (SPE)

UR - http://www.scopus.com/inward/record.url?scp=85184296796&partnerID=8YFLogxK

U2 - 10.1007/978-3-031-18810-7_10

DO - 10.1007/978-3-031-18810-7_10

M3 - Chapter

AN - SCOPUS:85184296796

SN - 9783031188091

SP - 503

EP - 569

BT - Radiobiology Textbook

PB - Springer International Publishing

ER -

Space Radiobiology

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