Sophisticated Magneto-Mechanical Actuation Promotes In Situ Stem Cell Assembly and Chondrogenesis for Treating Osteoarthritis

Cuijun Deng, Zhenguang Li, Laiya Lu, Huina Zhang, Runzhi Chen, Yali Liu, Yifan Tong, Orion R. Fan, Wanxin Huang, Yi Eve Sun*, Feng Yin*, Yu Cheng*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Abnormal mechanical loading often leads to the progressive degradation of cartilage and causes osteoarthritis (OA). Although multiple mechanoresponsive strategies based on biomaterials have been designed to restore healthy cartilage microenvironments, methods to remotely control the on-demand mechanical forces for cartilage repair pose significant challenges. Here, a magneto-mechanically controlled mesenchymal stem cell (MSC) platform, based on the integration of intercellular mechanical communication and intracellular mechanosignaling processes, is developed for OA treatment. MSCs loaded with antioxidative melanin@Fe3O4 magnetic nanoparticles (Magcells) rapidly assemble into highly ordered cell clusters with enhanced cell-cell communication under a time-varying magnetic field, which enables long-term retention and differentiation of Magcells in the articular cavity. Subsequently, via mimicking the gait cycle, chondrogenesis can be further enhanced by the dynamic activation of mechanical signaling processes in Magcells. This sophisticated magneto-mechanical actuation strategy provides a paradigm for developing mechano-therapeutics to repair cartilage in OA treatment.

Original languageEnglish
Pages (from-to)21690-21707
Number of pages18
JournalACS Nano
Volume17
Issue number21
DOIs
Publication statusPublished - 14 Nov 2023
Externally publishedYes

Keywords

  • chondrogenesis
  • magnetic field
  • magneto-mechanical actuation
  • OA treatment
  • stem cell assembly

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