Abstract
It is shown that a rational approach to planning multi-centre trials will lead to an unequal distribution of patients across centres. Consequently different approaches to estimation will yield different estimates. However, some such approaches are not reasonable and it is concluded that multi-centre trials are less problematic than is commonly supposed.
| Original language | English |
|---|---|
| Pages (from-to) | 1753-1765 |
| Number of pages | 13 |
| Journal | Statistics in Medicine |
| Volume | 17 |
| Issue number | 15-16 |
| DOIs | |
| Publication status | Published - 15 Aug 1998 |
| Externally published | Yes |