Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Ernesto Gargiulo; Elodie Viry; Etienne Moussay; Jerome Paggetti

doi:10.1080/2162402X.2022.2127507

Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Ernesto Gargiulo
, Elodie Viry
, Etienne Moussay^* (Main author)
, Jerome Paggetti

^*Corresponding author for this work

Tumor Stroma Interactions

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8⁺ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.

Original language	English
Article number	2127507
Pages (from-to)	2127507
Journal	OncoImmunology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2022.2127507
Publication status	Published - 27 Sept 2022

Keywords

CLL
exosomes
sEV-based biomarkers
Small extracellular vesicles
tumor immune escape
tumor microenvironment

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10.1080/2162402X.2022.2127507Licence: CC BY-NC

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title = "Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo",

abstract = "Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.",

keywords = "CLL, exosomes, sEV-based biomarkers, Small extracellular vesicles, tumor immune escape, tumor microenvironment",

author = "Ernesto Gargiulo and Elodie Viry and Etienne Moussay and Jerome Paggetti",

note = "Funding Information: This work was supported by grants from the Luxembourg National Research Fund (FNR) and Fondation Cancer, Luxembourg to EG, EM and JP (PRIDE15/10675146/CANBIO, INTER/DFG/16/11509946, C20/BM/14582635 and C20/BM/14592342) and from Fonds National de la Recherche Scientifique (FNRS)-T{\'e}l{\'e}vie to EV (7.4509.20). Publisher Copyright: {\textcopyright} 2022 The Author(s). Published with license by Taylor \& Francis Group, LLC.",

year = "2022",

month = sep,

day = "27",

doi = "10.1080/2162402X.2022.2127507",

language = "English",

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T1 - Small extracellular vesicles

T2 - multi-faceted tools for leukemia immune evasion in vivo

AU - Gargiulo, Ernesto

AU - Viry, Elodie

AU - Moussay, Etienne

AU - Paggetti, Jerome

N1 - Funding Information: This work was supported by grants from the Luxembourg National Research Fund (FNR) and Fondation Cancer, Luxembourg to EG, EM and JP (PRIDE15/10675146/CANBIO, INTER/DFG/16/11509946, C20/BM/14582635 and C20/BM/14592342) and from Fonds National de la Recherche Scientifique (FNRS)-Télévie to EV (7.4509.20). Publisher Copyright: © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

PY - 2022/9/27

Y1 - 2022/9/27

N2 - Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.

AB - Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.

KW - CLL

KW - exosomes

KW - sEV-based biomarkers

KW - Small extracellular vesicles

KW - tumor immune escape

KW - tumor microenvironment

UR - https://www.scopus.com/pages/publications/85138960126

UR - https://pubmed.ncbi.nlm.nih.gov/36185808

U2 - 10.1080/2162402X.2022.2127507

DO - 10.1080/2162402X.2022.2127507

M3 - Article

C2 - 36185808

AN - SCOPUS:85138960126

SN - 2162-4011

VL - 11

SP - 2127507

JO - OncoImmunology

JF - OncoImmunology

IS - 1

M1 - 2127507

ER -

Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Abstract

Keywords

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