@article{fe8b86996cb24c2eb9f994df65725ffc,
title = "Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo",
abstract = "Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.",
keywords = "CLL, exosomes, sEV-based biomarkers, Small extracellular vesicles, tumor immune escape, tumor microenvironment",
author = "Ernesto Gargiulo and Elodie Viry and Etienne Moussay and Jerome Paggetti",
note = "Funding Information: This work was supported by grants from the Luxembourg National Research Fund (FNR) and Fondation Cancer, Luxembourg to EG, EM and JP (PRIDE15/10675146/CANBIO, INTER/DFG/16/11509946, C20/BM/14582635 and C20/BM/14592342) and from Fonds National de la Recherche Scientifique (FNRS)-T{\'e}l{\'e}vie to EV (7.4509.20). Publisher Copyright: {\textcopyright} 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.",
year = "2022",
month = sep,
day = "27",
doi = "10.1080/2162402X.2022.2127507",
language = "English",
volume = "11",
pages = "2127507",
journal = "OncoImmunology",
issn = "2162-4011",
publisher = "Landes Bioscience",
number = "1",
}