Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Ernesto Gargiulo, Elodie Viry, Etienne Moussay*, Jerome Paggetti

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.

Original languageEnglish
Article number2127507
Pages (from-to)2127507
JournalOncoImmunology
Volume11
Issue number1
DOIs
Publication statusPublished - 27 Sep 2022

Keywords

  • CLL
  • exosomes
  • sEV-based biomarkers
  • Small extracellular vesicles
  • tumor immune escape
  • tumor microenvironment

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