Similar α-Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls

Laurent Antunes, Sonia Frasquilho, Marek Ostaszewski, Jos Weber, Laura Longhino, Paul Antony, Aidos Baumuratov, Manuel Buttini, Kathleen M. Shannon, Rudi Balling, Nico J. Diederich*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)


Background: The gut is proposed as a starting point of idiopathic IPD, but the presence of α-synuclein in the IPD colon mucosa is debated. Objectives: The objective of this study was to evaluate if α-synuclein in the colon mucosa can serve as a biomarker of IPD. Methods: Immunohistochemistry was used to locate and quantify in a blinded approach α-synuclein in the mucosa from biopsies of the right and left colon in 19 IPD patients and 8 controls. Results: Total α-synuclein was present in all but 1 IPD patients and in all controls; phosphorylated α-synuclein was present in all subjects. There was no intensity difference depending on disease status. Staining of total α-synuclein was stronger in the right colon (p =.04). Conclusions: Conventional immunohistochemistry α-synuclein staining in colon mucosal biopsies cannot serve as a biomarker of idiopathic PD. These findings do not contradict the assumption of disease starting in the colon, and a colon segment-specific risk for disease initiation can still be hypothesized.

Original languageEnglish
Pages (from-to)1567-1570
Number of pages4
JournalMovement Disorders
Issue number10
Publication statusPublished - 1 Oct 2016


  • Parkinson's disease
  • alpha-synuclein
  • biomarker
  • colon
  • mucosa


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