@article{2ed97ad39f684252b4ec9c15849f7f9f,
title = "Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections",
abstract = "Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reactivity in T-cell biology is incompletely understood. We addressed the role of self-reactivity in T-cell diversity by generating an atlas of mouse peripheral CD8+ T cells, which revealed two unconventional populations of antigen-inexperienced T cells. In the next step, we examined the steady-state phenotype of monoclonal T cells with various levels of self-reactivity. Highly self-reactive clones preferentially differentiate into antigen-inexperienced memory-like cells, but do not form a population expressing type I interferon-induced genes, showing that these two subsets have unrelated origins. The functional comparison of na{\"i}ve monoclonal CD8+ T cells specific to the identical model antigen did not show any correlation between the level of self-reactivity and the magnitude of the immune response.",
keywords = "antigen-inexperienced memory-like CD8 T cells, interferon response, self-reactivity, T cell, T-cell diversity",
author = "Darina Paprckova and Veronika Niederlova and Alena Moudra and Ales Drobek and Michaela Pribikova and Sarka Janusova and Kilian Schober and Ales Neuwirth and Juraj Michalik and Martina Huranova and Veronika Horkova and Michaela Cesnekova and Michaela Simova and Jan Prochazka and Jana Balounova and Busch, {Dirk H.} and Radislav Sedlacek and Martin Schwarzer and Ondrej Stepanek",
note = "Funding Information: The project was supported by the Czech Science Foundation (19-03435Y to OS and 21-19640M to MS), the Czech Academy of Sciences (RVO 68378050 to OS), the National Institute of virology and bacteriology (Programme EXCELES, ID Project No. LX22NPO5103) - Funded by the European Union - Next Generation EU, Charles University Grant Agency (838120 to VN), and the Czech Ministry of Education, Youth and Sports and the European Regional Development Fund (LM2015040, LM2018126, OP RDI CZ.1.05/2.1.00/19.0395, OP RDI BIOCEV CZ.1.05/1.1.00/02.0109 to RS). The contribution by DB was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) SFB 1054/3 - 210592381 (project B09) and SFB- TRR 338/1 2021 - 452881907 (project A01). Publisher Copyright: Copyright {\textcopyright} 2022 Paprckova, Niederlova, Moudra, Drobek, Pribikova, Janusova, Schober, Neuwirth, Michalik, Huranova, Horkova, Cesnekova, Simova, Prochazka, Balounova, Busch, Sedlacek, Schwarzer and Stepanek.",
year = "2022",
month = oct,
day = "6",
doi = "10.3389/fimmu.2022.1009198",
language = "English",
volume = "13",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",
}