TY - JOUR
T1 - Segmental determination of ethyl glucuronide in hair
T2 - A pilot study
AU - Appenzeller, Brice M.R.
AU - Agirman, Resmi
AU - Neuberg, Paul
AU - Yegles, Michel
AU - Wennig, Robert
N1 - Funding Information:
This work has been supported by grant SAN-02-001 from Luxembourg Ministry of Health.
PY - 2007/12/20
Y1 - 2007/12/20
N2 - Ethyl glucuronide (EtG) is a minor metabolite of ethanol. Its detection in hair is more and more studied in both clinical and forensic context for the purpose of alcohol abuse monitoring. In this pilot study, hair specimens from 15 patients included in a treatment program after alcohol abuse cessation, were segmented and analyzed for EtG. The results were then compared to their self-reported past alcohol consumption and to their blood biomarkers values (GGT, MCV, ASAT, ALAT). EtG concentrations measured in hair varied from 8 to 261 pg/mg. The pattern of EtG concentration detected in the different hair segments matched with the drinking history of patients, displaying variations (increase and decrease) in alcohol consumption and also time of cessation. Results also demonstrated the existence of a significant correlation (rp = 0.5357; p = 0.0390) between EtG concentration in hair and the amount of alcohol intake. Variations in the EtG concentrations with respect to hair segments may provide an overview of the drinking history of patients. Moreover, EtG concentration in hair may help to estimate the daily alcohol intake.
AB - Ethyl glucuronide (EtG) is a minor metabolite of ethanol. Its detection in hair is more and more studied in both clinical and forensic context for the purpose of alcohol abuse monitoring. In this pilot study, hair specimens from 15 patients included in a treatment program after alcohol abuse cessation, were segmented and analyzed for EtG. The results were then compared to their self-reported past alcohol consumption and to their blood biomarkers values (GGT, MCV, ASAT, ALAT). EtG concentrations measured in hair varied from 8 to 261 pg/mg. The pattern of EtG concentration detected in the different hair segments matched with the drinking history of patients, displaying variations (increase and decrease) in alcohol consumption and also time of cessation. Results also demonstrated the existence of a significant correlation (rp = 0.5357; p = 0.0390) between EtG concentration in hair and the amount of alcohol intake. Variations in the EtG concentrations with respect to hair segments may provide an overview of the drinking history of patients. Moreover, EtG concentration in hair may help to estimate the daily alcohol intake.
KW - Alcohol consumption
KW - Ethyl glucuronide
KW - Hair segmental analysis
UR - http://www.scopus.com/inward/record.url?scp=35349027815&partnerID=8YFLogxK
U2 - 10.1016/j.forsciint.2007.01.025
DO - 10.1016/j.forsciint.2007.01.025
M3 - Article
C2 - 17337139
AN - SCOPUS:35349027815
SN - 0379-0738
VL - 173
SP - 87
EP - 92
JO - Forensic Science International
JF - Forensic Science International
IS - 2-3
ER -