Rubella seroprevalence among pregnant women in Burkina Faso

Marc C. Tahita; Judith M. Hübschen; Zekiba Tarnagda; Da Ernest; Emilie Charpentier; Jacques R. Kremer; Claude P. Muller; Jean B. Ouedraogo

doi:10.1186/1471-2334-13-164

Rubella seroprevalence among pregnant women in Burkina Faso

Marc C. Tahita, Judith M. Hübschen, Zekiba Tarnagda, Da Ernest, Emilie Charpentier, Jacques R. Kremer, Claude P. Muller^*, Jean B. Ouedraogo

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Background: Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso.Methods: Between December 2007 and March 2008 serum samples were collected from 341 pregnant women in Bobo (n = 132, urban area) and Houndé (n = 209, rural area) and were tested for rubella-specific IgG antibodies with a commercial ELISA kit.Results: An overall seropositivity rate of 95.0% (324/341) was found, with a higher percentage in the urban population and in the oldest age group. Considering an antibody titer of at least 10 International Units per ml as protective, the overall immunity rate in the cohort of pregnant women was 93.3% (318/341).Conclusions: The high overall seropositivity rate in the absence of routine immunization suggests a continuous transmission of endemic rubella virus in Burkina Faso, posing a threat to non-immune pregnant women.

Original language	English
Article number	164
Journal	BMC Infectious Diseases
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/1471-2334-13-164
Publication status	Published - 4 Apr 2013

Keywords

Burkina Faso
IgG
Rubella
Seroprevalence

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10.1186/1471-2334-13-164

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title = "Rubella seroprevalence among pregnant women in Burkina Faso",

abstract = "Background: Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso.Methods: Between December 2007 and March 2008 serum samples were collected from 341 pregnant women in Bobo (n = 132, urban area) and Hound{\'e} (n = 209, rural area) and were tested for rubella-specific IgG antibodies with a commercial ELISA kit.Results: An overall seropositivity rate of 95.0% (324/341) was found, with a higher percentage in the urban population and in the oldest age group. Considering an antibody titer of at least 10 International Units per ml as protective, the overall immunity rate in the cohort of pregnant women was 93.3% (318/341).Conclusions: The high overall seropositivity rate in the absence of routine immunization suggests a continuous transmission of endemic rubella virus in Burkina Faso, posing a threat to non-immune pregnant women.",

keywords = "Burkina Faso, IgG, Rubella, Seroprevalence",

author = "Tahita, {Marc C.} and H{\"u}bschen, {Judith M.} and Zekiba Tarnagda and Da Ernest and Emilie Charpentier and Kremer, {Jacques R.} and Muller, {Claude P.} and Ouedraogo, {Jean B.}",

note = "Funding Information: We are grateful to all the women who participated in this study. We would also like to thank the entire medical, laboratory and administrative staffs at Hound{\'e} and the clinic Lorentia for their valuable contribution. We are grateful to Dr. Sankara Noufou and Dr. Lougue Guekon for their help to get the project started. The present study was financially supported by the Ministry of Foreign Affairs and the Centre de Recherche Public de la Sant{\'e} in Luxembourg and the Institut de Recherche en Sciences de la Sant{\'e} in Burkina Faso.",

year = "2013",

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doi = "10.1186/1471-2334-13-164",

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AU - Tahita, Marc C.

AU - Hübschen, Judith M.

AU - Tarnagda, Zekiba

AU - Ernest, Da

AU - Charpentier, Emilie

AU - Kremer, Jacques R.

AU - Muller, Claude P.

AU - Ouedraogo, Jean B.

N1 - Funding Information: We are grateful to all the women who participated in this study. We would also like to thank the entire medical, laboratory and administrative staffs at Houndé and the clinic Lorentia for their valuable contribution. We are grateful to Dr. Sankara Noufou and Dr. Lougue Guekon for their help to get the project started. The present study was financially supported by the Ministry of Foreign Affairs and the Centre de Recherche Public de la Santé in Luxembourg and the Institut de Recherche en Sciences de la Santé in Burkina Faso.

PY - 2013/4/4

Y1 - 2013/4/4

N2 - Background: Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso.Methods: Between December 2007 and March 2008 serum samples were collected from 341 pregnant women in Bobo (n = 132, urban area) and Houndé (n = 209, rural area) and were tested for rubella-specific IgG antibodies with a commercial ELISA kit.Results: An overall seropositivity rate of 95.0% (324/341) was found, with a higher percentage in the urban population and in the oldest age group. Considering an antibody titer of at least 10 International Units per ml as protective, the overall immunity rate in the cohort of pregnant women was 93.3% (318/341).Conclusions: The high overall seropositivity rate in the absence of routine immunization suggests a continuous transmission of endemic rubella virus in Burkina Faso, posing a threat to non-immune pregnant women.

AB - Background: Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso.Methods: Between December 2007 and March 2008 serum samples were collected from 341 pregnant women in Bobo (n = 132, urban area) and Houndé (n = 209, rural area) and were tested for rubella-specific IgG antibodies with a commercial ELISA kit.Results: An overall seropositivity rate of 95.0% (324/341) was found, with a higher percentage in the urban population and in the oldest age group. Considering an antibody titer of at least 10 International Units per ml as protective, the overall immunity rate in the cohort of pregnant women was 93.3% (318/341).Conclusions: The high overall seropositivity rate in the absence of routine immunization suggests a continuous transmission of endemic rubella virus in Burkina Faso, posing a threat to non-immune pregnant women.

KW - Burkina Faso

KW - IgG

KW - Rubella

KW - Seroprevalence

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Rubella seroprevalence among pregnant women in Burkina Faso

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