Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475

Siwen Niu; Ning Wang; Chun Lan Xie; Zuowang Fan; Zhuhua Luo; Hai Feng Chen; Xian Wen Yang

doi:10.1038/s41429-018-0046-y

Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475

Siwen Niu
, Ning Wang
, Chun Lan Xie
, Zuowang Fan
, Zhuhua Luo
, Hai Feng Chen
, Xian Wen Yang^*

^*Corresponding author for this work

Administrative Department & Core Services

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29 Citations (Scopus)

Abstract

Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2-5) roquefortine alkaloids, along with six ergosterol analogues (6-11). The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited potent anti-proliferative effects against HepG2 tumor cells with IC ₅₀ values of 7.0, 8.6, and 8.2 μM, respectively.

Original language	English
Pages (from-to)	658-661
Number of pages	4
Journal	Journal of Antibiotics
Volume	71
Issue number	7
DOIs	https://doi.org/10.1038/s41429-018-0046-y
Publication status	Published - 1 Jul 2018

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title = "Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475",

abstract = " Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2-5) roquefortine alkaloids, along with six ergosterol analogues (6-11). The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited potent anti-proliferative effects against HepG2 tumor cells with IC 50 values of 7.0, 8.6, and 8.2 μM, respectively.",

author = "Siwen Niu and Ning Wang and Xie, \{Chun Lan\} and Zuowang Fan and Zhuhua Luo and Chen, \{Hai Feng\} and Yang, \{Xian Wen\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s) under exclusive licence to the Japan Antibiotics Research Association.",

year = "2018",

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doi = "10.1038/s41429-018-0046-y",

language = "English",

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T1 - Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475

AU - Niu, Siwen

AU - Wang, Ning

AU - Xie, Chun Lan

AU - Fan, Zuowang

AU - Luo, Zhuhua

AU - Chen, Hai Feng

AU - Yang, Xian Wen

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2-5) roquefortine alkaloids, along with six ergosterol analogues (6-11). The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited potent anti-proliferative effects against HepG2 tumor cells with IC 50 values of 7.0, 8.6, and 8.2 μM, respectively.

AB - Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2-5) roquefortine alkaloids, along with six ergosterol analogues (6-11). The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited potent anti-proliferative effects against HepG2 tumor cells with IC 50 values of 7.0, 8.6, and 8.2 μM, respectively.

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ER -

Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475

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