TY - JOUR
T1 - Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475
AU - Niu, Siwen
AU - Wang, Ning
AU - Xie, Chun Lan
AU - Fan, Zuowang
AU - Luo, Zhuhua
AU - Chen, Hai Feng
AU - Yang, Xian Wen
N1 - Publisher Copyright:
© 2018 The Author(s) under exclusive licence to the Japan Antibiotics Research Association.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2-5) roquefortine alkaloids, along with six ergosterol analogues (6-11). The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited potent anti-proliferative effects against HepG2 tumor cells with IC 50 values of 7.0, 8.6, and 8.2 μM, respectively.
AB - Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2-5) roquefortine alkaloids, along with six ergosterol analogues (6-11). The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited potent anti-proliferative effects against HepG2 tumor cells with IC 50 values of 7.0, 8.6, and 8.2 μM, respectively.
UR - http://www.scopus.com/inward/record.url?scp=85044944737&partnerID=8YFLogxK
U2 - 10.1038/s41429-018-0046-y
DO - 10.1038/s41429-018-0046-y
M3 - Article
C2 - 29618769
AN - SCOPUS:85044944737
SN - 0021-8820
VL - 71
SP - 658
EP - 661
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 7
ER -