Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475

Siwen Niu, Ning Wang, Chun Lan Xie, Zuowang Fan, Zhuhua Luo, Hai Feng Chen, Xian Wen Yang*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2-5) roquefortine alkaloids, along with six ergosterol analogues (6-11). The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited potent anti-proliferative effects against HepG2 tumor cells with IC 50 values of 7.0, 8.6, and 8.2 μM, respectively.

Original languageEnglish
Pages (from-to)658-661
Number of pages4
JournalJournal of Antibiotics
Volume71
Issue number7
DOIs
Publication statusPublished - 1 Jul 2018

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