Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus

Oana Patricia Zaharia; Klaus Strassburger; Birgit Knebel; Christian Binsch; Yuliya Kupriyanova; Clara Möser; Kálmán Bódis; Katsiaryna Prystupa; Iryna Yurchenko; Dania Marel Mendez Cardenas; Martin Schön; Christian Herder; Hadi Al-Hasani; Vera Schrauwen-Hinderling; Karin Jandeleit-Dahm; Robert Wagner; Michael Roden; GDS Group

doi:10.1016/j.dsx.2024.103137

Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus

Oana Patricia Zaharia
, Klaus Strassburger
, Birgit Knebel
, Christian Binsch
, Yuliya Kupriyanova
, Clara Möser
, Kálmán Bódis
, Katsiaryna Prystupa
, Iryna Yurchenko
, Dania Marel Mendez Cardenas
, Martin Schön
, Christian Herder
, Hadi Al-Hasani
, Vera Schrauwen-Hinderling
, Karin Jandeleit-Dahm
, Robert Wagner
, Michael Roden
, GDS Group

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

AIMS: We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (PNPLA3) gene, with chronic kidney disease in diabetes endotypes.

METHODS: Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).

RESULTS: Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.05). HCL was negatively associated with eGFR (r = -0.287, p < 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 % for eGFR >60 ml/min to 52 % for eGFR <60 ml/min (p < 0.05).

CONCLUSIONS: The PNPLA3 polymorphism may contribute to declining kidney function independently of liver lipids.

Original language	English
Pages (from-to)	103137
Journal	Diabetes and Metabolic Syndrome: Clinical Research and Reviews
Volume	18
Issue number	10
DOIs	https://doi.org/10.1016/j.dsx.2024.103137
Publication status	Published - Oct 2024
Externally published	Yes

Keywords

Humans
Male
Female
Polymorphism, Single Nucleotide
Middle Aged
Lipase/genetics
Glomerular Filtration Rate
Membrane Proteins/genetics
Prospective Studies
Adult
Diabetes Mellitus, Type 2/genetics
Renal Insufficiency, Chronic/genetics
Follow-Up Studies
Prognosis
Genotype
Biomarkers/analysis
Insulin Resistance/genetics
Acyltransferases
Phospholipases A2, Calcium-Independent

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10.1016/j.dsx.2024.103137

Cite this

Zaharia, O. P., Strassburger, K., Knebel, B., Binsch, C., Kupriyanova, Y., Möser, C., Bódis, K., Prystupa, K., Yurchenko, I., Mendez Cardenas, D. M., Schön, M., Herder, C., Al-Hasani, H., Schrauwen-Hinderling, V., Jandeleit-Dahm, K., Wagner, R., Roden, M., & GDS Group (2024). Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 18(10), 103137. https://doi.org/10.1016/j.dsx.2024.103137

@article{4ee053ca7f924f16a985381d57458f30,

title = "Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus",

abstract = "AIMS: We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (PNPLA3) gene, with chronic kidney disease in diabetes endotypes.METHODS: Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).RESULTS: Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.05). HCL was negatively associated with eGFR (r = -0.287, p < 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 \% for eGFR >60 ml/min to 52 \% for eGFR <60 ml/min (p < 0.05).CONCLUSIONS: The PNPLA3 polymorphism may contribute to declining kidney function independently of liver lipids.",

keywords = "Humans, Male, Female, Polymorphism, Single Nucleotide, Middle Aged, Lipase/genetics, Glomerular Filtration Rate, Membrane Proteins/genetics, Prospective Studies, Adult, Diabetes Mellitus, Type 2/genetics, Renal Insufficiency, Chronic/genetics, Follow-Up Studies, Prognosis, Genotype, Biomarkers/analysis, Insulin Resistance/genetics, Acyltransferases, Phospholipases A2, Calcium-Independent",

author = "Zaharia, \{Oana Patricia\} and Klaus Strassburger and Birgit Knebel and Christian Binsch and Yuliya Kupriyanova and Clara M{\"o}ser and K{\'a}lm{\'a}n B{\'o}dis and Katsiaryna Prystupa and Iryna Yurchenko and \{Mendez Cardenas\}, \{Dania Marel\} and Martin Sch{\"o}n and Christian Herder and Hadi Al-Hasani and Vera Schrauwen-Hinderling and Karin Jandeleit-Dahm and Robert Wagner and Michael Roden and \{GDS Group\}",

note = "Copyright {\textcopyright} 2024 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved.",

year = "2024",

month = oct,

doi = "10.1016/j.dsx.2024.103137",

language = "English",

volume = "18",

pages = "103137",

journal = "Diabetes and Metabolic Syndrome: Clinical Research and Reviews",

issn = "1871-4021",

publisher = "Diabetes India",

number = "10",

}

Zaharia, OP, Strassburger, K, Knebel, B, Binsch, C, Kupriyanova, Y, Möser, C, Bódis, K, Prystupa, K, Yurchenko, I, Mendez Cardenas, DM, Schön, M, Herder, C, Al-Hasani, H, Schrauwen-Hinderling, V, Jandeleit-Dahm, K, Wagner, R, Roden, M & GDS Group 2024, 'Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus', Diabetes and Metabolic Syndrome: Clinical Research and Reviews, vol. 18, no. 10, pp. 103137. https://doi.org/10.1016/j.dsx.2024.103137

Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus. / Zaharia, Oana Patricia; Strassburger, Klaus; Knebel, Birgit et al.
In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews, Vol. 18, No. 10, 10.2024, p. 103137.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus

AU - Zaharia, Oana Patricia

AU - Strassburger, Klaus

AU - Knebel, Birgit

AU - Binsch, Christian

AU - Kupriyanova, Yuliya

AU - Möser, Clara

AU - Bódis, Kálmán

AU - Prystupa, Katsiaryna

AU - Yurchenko, Iryna

AU - Mendez Cardenas, Dania Marel

AU - Schön, Martin

AU - Herder, Christian

AU - Al-Hasani, Hadi

AU - Schrauwen-Hinderling, Vera

AU - Jandeleit-Dahm, Karin

AU - Wagner, Robert

AU - Roden, Michael

AU - GDS Group

PY - 2024/10

Y1 - 2024/10

N2 - AIMS: We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (PNPLA3) gene, with chronic kidney disease in diabetes endotypes.METHODS: Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).RESULTS: Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.05). HCL was negatively associated with eGFR (r = -0.287, p < 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 % for eGFR >60 ml/min to 52 % for eGFR <60 ml/min (p < 0.05).CONCLUSIONS: The PNPLA3 polymorphism may contribute to declining kidney function independently of liver lipids.

AB - AIMS: We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (PNPLA3) gene, with chronic kidney disease in diabetes endotypes.METHODS: Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).RESULTS: Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.05). HCL was negatively associated with eGFR (r = -0.287, p < 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 % for eGFR >60 ml/min to 52 % for eGFR <60 ml/min (p < 0.05).CONCLUSIONS: The PNPLA3 polymorphism may contribute to declining kidney function independently of liver lipids.

KW - Humans

KW - Male

KW - Female

KW - Polymorphism, Single Nucleotide

KW - Middle Aged

KW - Lipase/genetics

KW - Glomerular Filtration Rate

KW - Membrane Proteins/genetics

KW - Prospective Studies

KW - Adult

KW - Diabetes Mellitus, Type 2/genetics

KW - Renal Insufficiency, Chronic/genetics

KW - Follow-Up Studies

KW - Prognosis

KW - Genotype

KW - Biomarkers/analysis

KW - Insulin Resistance/genetics

KW - Acyltransferases

KW - Phospholipases A2, Calcium-Independent

U2 - 10.1016/j.dsx.2024.103137

DO - 10.1016/j.dsx.2024.103137

M3 - Article

C2 - 39427597

SN - 1871-4021

VL - 18

SP - 103137

JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

IS - 10

ER -

Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus

Abstract

Keywords

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