TY - JOUR
T1 - Role of Genetic Ancestry in 1,002 Brazilian Colorectal Cancer Patients From Barretos Cancer Hospital
AU - Durães, Ronilson Oliveira
AU - Berardinelli, Gustavo Noriz
AU - da Costa, Allini Mafra
AU - Scapulatempo-Neto, Cristovam
AU - Pereira, Rui
AU - Oliveira, Marco Antônio
AU - Guimarães, Denise Peixoto
AU - Reis, Rui Manuel
N1 - Funding Information:
The authors thank the Hospital-Based Cancer Registry of Barretos Cancer Hospital (São Paulo, Brazil) for the collaboration in updating the follow-up status of the patients. Funding. This study was partially supported by Barretos Cancer Hospital Internal Research Funds (PAIP) of participant authors and Public Ministry of Labor Campinas (Research, Prevention and Education of Occupational Cancer). RR was the recipient of a National Council of Technological and Scientific Development (CNPq) scholarship. AC is recipient of a FAPESP post-doc fellowship (2018/22097-0).
Funding Information:
This study was partially supported by Barretos Cancer Hospital Internal Research Funds (PAIP) of participant authors and Public Ministry of Labor Campinas (Research, Prevention and Education of Occupational Cancer). RR was the recipient of a National Council of Technological and Scientific Development (CNPq) scholarship. AC is recipient of a FAPESP post-doc fellowship (2018/22097-0).
Publisher Copyright:
© Copyright © 2020 Durães, Berardinelli, da Costa, Scapulatempo-Neto, Pereira, Oliveira, Guimarães and Reis.
PY - 2020/3/4
Y1 - 2020/3/4
N2 - Background: Colorectal cancer (CRC) is the third most frequent and the second deadliest cancer worldwide. The ethnic structure of the population has been gaining prominence as a cancer player. The purpose of this study was to determine the genetic ancestry of Brazilian CRC patients. Moreover, we intended to interrogate its impact on patients' clinicopathological features. Methods: Retrospective observational cohort study with 1,002 patients with CRC admitted from 2000 to 2014 at Barretos Cancer Hospital. Following tumor DNA isolation, genetic ancestry was assessed using a specific panel of 46 ancestry informative markers. Survival rates were obtained by the Kaplan–Meier method, and the log-rank test was used to compare the survival curves. Multivariable Cox proportional regression models were used to estimate hazard ratios (HRs). Results: We observed considerable admixture in the genetic composition, with the following average proportions: European 74.2%, African 12.7%, Asian 6.5%, and Amerindian 6.6%. The multivariate analysis for cancer-specific survival showed that clinical stage, lymphovascular invasion, and the presence of recurrence were associated with an increased relative risk of death from cancer (p < 0.05). High African proportion was associated with younger age at diagnosis, while high Amerindian proportion was associated with the mucinous histological subtype. Conclusions: This represents the larger assessment of genetic ancestry in a population of Brazilian patients with CRC. Brazilian CRC patients exhibited similar clinicopathological features as described in Western countries. Impact: Genetic ancestry components corroborated the significant admixture, and importantly, patients with high African proportion develop cancer at a younger age.
AB - Background: Colorectal cancer (CRC) is the third most frequent and the second deadliest cancer worldwide. The ethnic structure of the population has been gaining prominence as a cancer player. The purpose of this study was to determine the genetic ancestry of Brazilian CRC patients. Moreover, we intended to interrogate its impact on patients' clinicopathological features. Methods: Retrospective observational cohort study with 1,002 patients with CRC admitted from 2000 to 2014 at Barretos Cancer Hospital. Following tumor DNA isolation, genetic ancestry was assessed using a specific panel of 46 ancestry informative markers. Survival rates were obtained by the Kaplan–Meier method, and the log-rank test was used to compare the survival curves. Multivariable Cox proportional regression models were used to estimate hazard ratios (HRs). Results: We observed considerable admixture in the genetic composition, with the following average proportions: European 74.2%, African 12.7%, Asian 6.5%, and Amerindian 6.6%. The multivariate analysis for cancer-specific survival showed that clinical stage, lymphovascular invasion, and the presence of recurrence were associated with an increased relative risk of death from cancer (p < 0.05). High African proportion was associated with younger age at diagnosis, while high Amerindian proportion was associated with the mucinous histological subtype. Conclusions: This represents the larger assessment of genetic ancestry in a population of Brazilian patients with CRC. Brazilian CRC patients exhibited similar clinicopathological features as described in Western countries. Impact: Genetic ancestry components corroborated the significant admixture, and importantly, patients with high African proportion develop cancer at a younger age.
KW - cancer outcome
KW - colorectal cancer
KW - colorectal cancer survival
KW - genetic ancestry
KW - prognostic factors
UR - http://www.scopus.com/inward/record.url?scp=85082616621&partnerID=8YFLogxK
U2 - 10.3389/fonc.2020.00145
DO - 10.3389/fonc.2020.00145
M3 - Article
AN - SCOPUS:85082616621
SN - 2234-943X
VL - 10
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 145
ER -