Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat

Christiane Hilger; Jörg Fischer; Florian Wölbing; Tilo Biedermann

doi:10.1007/s11882-019-0835-9

Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat

Christiane Hilger^*, Jörg Fischer, Florian Wölbing, Tilo Biedermann

^*Corresponding author for this work

Molecular and Translational Allergology

Research output: Contribution to journal › Review article › peer-review

75 Citations (Scopus)

Abstract

Purpose of Review: The alpha-Gal (α-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (α-Gal). In this article, we review the presence of α-Gal in food and non-food sources; we discuss the evolutionary context of the antibody response to α-Gal and highlight immune responses to α-Gal and other carbohydrates. Recent findings: IgE antibodies have been associated with delayed allergy to red meat. In addition to food, drugs, and other products of animal origin are increasingly perceived as a risk for patients sensitized to α-Gal. The link between tick bites and anti-α-Gal IgE-antibody production that has been established first by epidemiological studies has now been confirmed in mouse models. Summary: The anti-α-Gal immune response is complex and characterized by a unique feature. IgM and IgG antibodies have been found to confer protection against pathogens whereas the IgE-response to α-Gal is detrimental and causes severe reactions upon exposure to mammalian meat and other products.

Original language	English
Article number	3
Journal	Current Allergy and Asthma Reports
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/s11882-019-0835-9
Publication status	Published - 1 Jan 2019

Keywords

Alpha-gal
Carbohydrate
Food allergy
Red meat allergy
Tick

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10.1007/s11882-019-0835-9

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title = "Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat",

abstract = "Purpose of Review: The alpha-Gal (α-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (α-Gal). In this article, we review the presence of α-Gal in food and non-food sources; we discuss the evolutionary context of the antibody response to α-Gal and highlight immune responses to α-Gal and other carbohydrates. Recent findings: IgE antibodies have been associated with delayed allergy to red meat. In addition to food, drugs, and other products of animal origin are increasingly perceived as a risk for patients sensitized to α-Gal. The link between tick bites and anti-α-Gal IgE-antibody production that has been established first by epidemiological studies has now been confirmed in mouse models. Summary: The anti-α-Gal immune response is complex and characterized by a unique feature. IgM and IgG antibodies have been found to confer protection against pathogens whereas the IgE-response to α-Gal is detrimental and causes severe reactions upon exposure to mammalian meat and other products.",

keywords = "Alpha-gal, Carbohydrate, Food allergy, Red meat allergy, Tick",

author = "Christiane Hilger and J{\"o}rg Fischer and Florian W{\"o}lbing and Tilo Biedermann",

note = "Funding Information: Funding This work was supported with a bilateral funding from the Luxembourg National Research Fund (FNR), project C17/BM/ 11656090, and the Deutsche Forschungsgemeinschaft (DFG), project BI 696/12–1 and FI 2226/2–1, as well as by grants from the DFG (SFB 1371, SPP1394 BI 696/5–2). Publisher Copyright: {\textcopyright} 2019, The Author(s).",

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doi = "10.1007/s11882-019-0835-9",

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AU - Hilger, Christiane

AU - Fischer, Jörg

AU - Wölbing, Florian

AU - Biedermann, Tilo

N1 - Funding Information: Funding This work was supported with a bilateral funding from the Luxembourg National Research Fund (FNR), project C17/BM/ 11656090, and the Deutsche Forschungsgemeinschaft (DFG), project BI 696/12–1 and FI 2226/2–1, as well as by grants from the DFG (SFB 1371, SPP1394 BI 696/5–2). Publisher Copyright: © 2019, The Author(s).

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose of Review: The alpha-Gal (α-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (α-Gal). In this article, we review the presence of α-Gal in food and non-food sources; we discuss the evolutionary context of the antibody response to α-Gal and highlight immune responses to α-Gal and other carbohydrates. Recent findings: IgE antibodies have been associated with delayed allergy to red meat. In addition to food, drugs, and other products of animal origin are increasingly perceived as a risk for patients sensitized to α-Gal. The link between tick bites and anti-α-Gal IgE-antibody production that has been established first by epidemiological studies has now been confirmed in mouse models. Summary: The anti-α-Gal immune response is complex and characterized by a unique feature. IgM and IgG antibodies have been found to confer protection against pathogens whereas the IgE-response to α-Gal is detrimental and causes severe reactions upon exposure to mammalian meat and other products.

AB - Purpose of Review: The alpha-Gal (α-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (α-Gal). In this article, we review the presence of α-Gal in food and non-food sources; we discuss the evolutionary context of the antibody response to α-Gal and highlight immune responses to α-Gal and other carbohydrates. Recent findings: IgE antibodies have been associated with delayed allergy to red meat. In addition to food, drugs, and other products of animal origin are increasingly perceived as a risk for patients sensitized to α-Gal. The link between tick bites and anti-α-Gal IgE-antibody production that has been established first by epidemiological studies has now been confirmed in mouse models. Summary: The anti-α-Gal immune response is complex and characterized by a unique feature. IgM and IgG antibodies have been found to confer protection against pathogens whereas the IgE-response to α-Gal is detrimental and causes severe reactions upon exposure to mammalian meat and other products.

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KW - Carbohydrate

KW - Food allergy

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KW - Tick

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Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat

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