Robust and realistic approaches to carry-over

Stephen Senn*, Dimitrios Lambrou

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)


The relationship between choice of model for carry-over and choice of efficient cross-over design is studied in particular with reference to two treatment designs in four periods and two sequences. The effect of model miss-specification is also examined. It is concluded that previous claims regarding efficient designs are not necessarily reasonable.

Original languageEnglish
Pages (from-to)2849-2864
Number of pages16
JournalStatistics in Medicine
Issue number24
Publication statusPublished - 30 Dec 1998
Externally publishedYes


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