TY - JOUR
T1 - Resistant starch improves Parkinson’s disease symptoms through restructuring of the gut microbiome and modulating inflammation
AU - Petrov, Viacheslav A.
AU - Schade, Sebastian
AU - Laczny, Cedric C.
AU - Hällqvist, Jenny
AU - May, Patrick
AU - Jäger, Christian
AU - Aho, Velma T.E.
AU - Hickl, Oskar
AU - Halder, Rashi
AU - Lang, Elisabeth
AU - Caussin, Jordan
AU - Lebrun, Laura A.
AU - Schulz, Janine
AU - Unger, Marcus Michael
AU - Mills, Kevin
AU - Mollenhauer, Brit
AU - Wilmes, Paul
N1 - Funding:
This project has received funding from the Michael J. Fox Foundation (PARKdiet MJFF-019228), the Luxembourg National Research Fund
(FNR, MICROH DTU PRIDE/11823097), the Institute for Advanced
Studies of the University of Luxembourg (AUDACITY grant MCI-
BIOME_2019), and the European Research Council (ERC) under the
European Union’s Horizon 2020 research and innovation programme
(grant agreement No. 863664) to P.W. Additional funding was provided
by the Deutsche Forschungsgemeinschaft (DFG) Research Unit FOR2488
(INTER/DFG/19/14429377), and the FNR under the National Center of
Excellence in Research on Parkinson’s disease (NCER-PD,
FNR11264123) to P.M. This work was also supported by a Fulbright
Research Scholarship from the Commission for Educational Exchange
between the United States, Belgium and Luxembourg and by the FNR
under INTERMOBILITY/23/17856242 to P.W.
Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2026/2
Y1 - 2026/2
N2 - Alterations in the gut microbiome and a “leaky” gut are associated with Parkinson’s disease (PD), which implies the prospect of rebalancing via dietary intervention. Here, we investigate the impact of a diet rich in resistant starch on the gut microbiome through a multi-omics approach. We conducted a randomized, controlled trial with short-term and long-term phases involving 74 PD patients of three groups: conventional diet, supplementation with resistant starch, and high-fibre diet. Our findings reveal associations between dietary patterns and changes in the gut microbiome’s taxonomic composition, functional potential, metabolic activity, and host inflammatory proteome response. Resistant starch supplementation led to an increase in Faecalibacterium species and short-chain fatty acids alongside a reduction in opportunistic pathogens. Long-term supplementation also increased blood APOA4 and HSPA5 and reduced symptoms of PD. Our study highlights the potential of dietary interventions to modulate the gut microbiome and improve the quality of life for PD patients.
AB - Alterations in the gut microbiome and a “leaky” gut are associated with Parkinson’s disease (PD), which implies the prospect of rebalancing via dietary intervention. Here, we investigate the impact of a diet rich in resistant starch on the gut microbiome through a multi-omics approach. We conducted a randomized, controlled trial with short-term and long-term phases involving 74 PD patients of three groups: conventional diet, supplementation with resistant starch, and high-fibre diet. Our findings reveal associations between dietary patterns and changes in the gut microbiome’s taxonomic composition, functional potential, metabolic activity, and host inflammatory proteome response. Resistant starch supplementation led to an increase in Faecalibacterium species and short-chain fatty acids alongside a reduction in opportunistic pathogens. Long-term supplementation also increased blood APOA4 and HSPA5 and reduced symptoms of PD. Our study highlights the potential of dietary interventions to modulate the gut microbiome and improve the quality of life for PD patients.
KW - Dietary intervention
KW - Inflammatory proteome
KW - Metabolome
KW - Metagenome
KW - Microbiome
KW - Parkinson’s Disease
KW - Resistant starch
UR - https://www.scopus.com/pages/publications/105025356572
UR - https://pubmed.ncbi.nlm.nih.gov/41389850/
U2 - 10.1016/j.bbi.2025.106217
DO - 10.1016/j.bbi.2025.106217
M3 - Article
C2 - 41389850
AN - SCOPUS:105025356572
SN - 0889-1591
VL - 132
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
M1 - 106217
ER -