Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

Francesca Liuzzi; Claudia Fanelli; Maria Rosa Ciriolo; Claudia Cerella; Maria D'Alessio; Milena Denicola; Andrea Magrini; Antonio Bergamaschi; Lina Ghibelli

doi:10.1196/annals.1299.080

Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

Francesca Liuzzi
, Claudia Fanelli
, Maria Rosa Ciriolo
, Claudia Cerella
, Maria D'Alessio
, Milena Denicola
, Andrea Magrini
, Antonio Bergamaschi
, Lina Ghibelli^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Abstract

Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO₂, 95% N₂)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.

Original language	English
Pages (from-to)	441-445
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1010
DOIs	https://doi.org/10.1196/annals.1299.080
Publication status	Published - 2003
Externally published	Yes

Keywords

Antioxidants
Apoptosis
Glutathione

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10.1196/annals.1299.080

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title = "Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion",

abstract = "Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5\%CO2, 95\% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\textbackslash{}s oxidation and radical production.",

keywords = "Antioxidants, Apoptosis, Glutathione",

author = "Francesca Liuzzi and Claudia Fanelli and Ciriolo, \{Maria Rosa\} and Claudia Cerella and Maria D'Alessio and Milena Denicola and Andrea Magrini and Antonio Bergamaschi and Lina Ghibelli",

year = "2003",

doi = "10.1196/annals.1299.080",

language = "English",

volume = "1010",

pages = "441--445",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc",

}

TY - JOUR

T1 - Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

AU - Liuzzi, Francesca

AU - Fanelli, Claudia

AU - Ciriolo, Maria Rosa

AU - Cerella, Claudia

AU - D'Alessio, Maria

AU - Denicola, Milena

AU - Magrini, Andrea

AU - Bergamaschi, Antonio

AU - Ghibelli, Lina

PY - 2003

Y1 - 2003

N2 - Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.

AB - Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.

KW - Antioxidants

KW - Apoptosis

KW - Glutathione

UR - https://www.scopus.com/pages/publications/1342284274

U2 - 10.1196/annals.1299.080

DO - 10.1196/annals.1299.080

M3 - Article

C2 - 15033767

AN - SCOPUS:1342284274

SN - 0077-8923

VL - 1010

SP - 441

EP - 445

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

Abstract

Keywords

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