Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

Francesca Liuzzi; Claudia Fanelli; Maria Rosa Ciriolo; Claudia Cerella; Maria D'Alessio; Milena Denicola; Andrea Magrini; Antonio Bergamaschi; Lina Ghibelli

doi:10.1196/annals.1299.080

Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

Francesca Liuzzi, Claudia Fanelli, Maria Rosa Ciriolo, Claudia Cerella, Maria D'Alessio, Milena Denicola, Andrea Magrini, Antonio Bergamaschi, Lina Ghibelli^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Abstract

Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO₂, 95% N₂)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.

Original language	English
Pages (from-to)	441-445
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1010
DOIs	https://doi.org/10.1196/annals.1299.080
Publication status	Published - 2003
Externally published	Yes

Keywords

Antioxidants
Apoptosis
Glutathione

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title = "Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion",

abstract = "Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.",

keywords = "Antioxidants, Apoptosis, Glutathione",

author = "Francesca Liuzzi and Claudia Fanelli and Ciriolo, {Maria Rosa} and Claudia Cerella and Maria D'Alessio and Milena Denicola and Andrea Magrini and Antonio Bergamaschi and Lina Ghibelli",

year = "2003",

doi = "10.1196/annals.1299.080",

language = "English",

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pages = "441--445",

journal = "Annals of the New York Academy of Sciences",

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TY - JOUR

T1 - Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

AU - Liuzzi, Francesca

AU - Fanelli, Claudia

AU - Ciriolo, Maria Rosa

AU - Cerella, Claudia

AU - D'Alessio, Maria

AU - Denicola, Milena

AU - Magrini, Andrea

AU - Bergamaschi, Antonio

AU - Ghibelli, Lina

PY - 2003

Y1 - 2003

N2 - Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.

AB - Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.

KW - Antioxidants

KW - Apoptosis

KW - Glutathione

UR - http://www.scopus.com/inward/record.url?scp=1342284274&partnerID=8YFLogxK

U2 - 10.1196/annals.1299.080

DO - 10.1196/annals.1299.080

M3 - Article

C2 - 15033767

AN - SCOPUS:1342284274

SN - 0077-8923

VL - 1010

SP - 441

EP - 445

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

Abstract

Keywords

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