Replacement of sublineages of avian influenza (H5N1) by reassortments, sub-Saharan Africa

Ademola A. Owoade, Nancy A. Gerloff, Mariette F. Ducatez, Jolaoso O. Taiwo, Jacques R. Kremer, Claude P. Muller

    Research output: Contribution to journalArticleResearchpeer-review

    20 Citations (Scopus)

    Abstract

    Eight new full-length sequences from highly pathogenic avian influenza virus (H5N1) from 4 states in southwest Nigeria were analyzed. All gene sequences were more closely related to the first strains found in Nigeria in 2006 than to any strain found outside the country. Six viruses had evolved by at least 3 reassortment events (ACHA/NS, ACNS) from previously identified sublineages A (EMA 2) and C (EMA 1). Our results suggest that highly pathogenic avian influenza virus (H5N1) initially imported into Nigeria in 2006 have been gradually replaced by various reassortments. In all reassortants, nonstructural genes were derived from sublineage C with 2 characteristic amino acids (compared with sublineage A). If the high prevalence of reassortants was typical for West Africa in 2007, the absence of such reassortants anywhere else suggests that reintroductions of influenza A (H5N1) from Africa into Eurasia must be rare.

    Original languageEnglish
    Pages (from-to)1731-1735
    Number of pages5
    JournalEmerging Infectious Diseases
    Volume14
    Issue number11
    DOIs
    Publication statusPublished - Nov 2008

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