TY - JOUR
T1 - Repeated measures in clinical trials
T2 - Simple strategies for analysis using summary measures
AU - Senn, Stephen
AU - Stevens, Lynda
AU - Chaturvedi, Nish
PY - 2000/3/30
Y1 - 2000/3/30
N2 - The summary measures approach to analysing repeated measures is described. The circumstances under which it can be advantageous to use such measures are considered. Strategies for baseline adjustment where there are multiple baselines are examined, as is the choice of appropriate summary statistic. A compromise trend/mean measure, regression through the origin, is proposed as being useful under some circumstances. An analysis using this measure is illustrated with a suitable example. Copyright (C) 2000 John Wiley and Sons, Ltd.
AB - The summary measures approach to analysing repeated measures is described. The circumstances under which it can be advantageous to use such measures are considered. Strategies for baseline adjustment where there are multiple baselines are examined, as is the choice of appropriate summary statistic. A compromise trend/mean measure, regression through the origin, is proposed as being useful under some circumstances. An analysis using this measure is illustrated with a suitable example. Copyright (C) 2000 John Wiley and Sons, Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0034732105&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0258(20000330)19:6<861::AID-SIM407>3.0.CO;2-F
DO - 10.1002/(SICI)1097-0258(20000330)19:6<861::AID-SIM407>3.0.CO;2-F
M3 - Review article
C2 - 10734289
AN - SCOPUS:0034732105
SN - 0277-6715
VL - 19
SP - 861
EP - 877
JO - Statistics in Medicine
JF - Statistics in Medicine
IS - 6
ER -