Repeated measures in clinical trials: Simple strategies for analysis using summary measures

Stephen Senn*, Lynda Stevens, Nish Chaturvedi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

100 Citations (Scopus)

Abstract

The summary measures approach to analysing repeated measures is described. The circumstances under which it can be advantageous to use such measures are considered. Strategies for baseline adjustment where there are multiple baselines are examined, as is the choice of appropriate summary statistic. A compromise trend/mean measure, regression through the origin, is proposed as being useful under some circumstances. An analysis using this measure is illustrated with a suitable example. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)861-877
Number of pages17
JournalStatistics in Medicine
Volume19
Issue number6
DOIs
Publication statusPublished - 30 Mar 2000
Externally publishedYes

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