TY - JOUR
T1 - Relationship between entomological inoculation rate, Plasmodium falciparum prevalence rate, and incidence of malaria attack in rural Gabon
AU - Elissa, N.
AU - Migot-Nabias, F.
AU - Luty, A.
AU - Renaut, A.
AU - Touré, F.
AU - Vaillant, M.
AU - Lawoko, M.
AU - Yangari, P.
AU - Mayombo, J.
AU - Lekoulou, F.
AU - Tshipamba, P.
AU - Moukagni, R.
AU - Millet, P.
AU - Deloron, P.
N1 - Funding Information:
We thank Dr Jérôme Reltien, Hélène Tiga, and Hoppe Lewobo for help in collecting data in Dienga. The Dienga study was partially supported by a North–South Network INSERM grant (94-NS1). CIRMF is financed by the Gabonese government, ELF Gabon, and the French Ministry of Foreign Affairs.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - To assess the relationships between variations of Plasmodium falciparum transmission and those of peripheral parasitaemia prevalence or malaria attack incidence rates in regions with limited fluctuations of transmission, we conducted a follow-up in two Gabonese populations. Entomological surveys were carried out from May 1995 to April 1996 in Dienga, and from May 1998 to April 1999 in Benguia. In Dienga, malaria transmission was seasonal, being not detected during two 3-month periods. Mean entomological inoculation rate (EIR) was 0.28 infective bite/person/night. In Benguia, malaria transmission was perennial with seasonal fluctuations, mean EIR being 0.76 infective bite/person/night. In Dienga, 301 schoolchildren were followed from October 1995 to March 1996. Clinical malaria attack was defined as fever associated with >5000 parasites/μl of blood. P. falciparum prevalence varied from 28 to 42%, and monthly malaria attack incidence from 30 to 169‰. In Benguia, the entire population (122 persons) was followed from November 1998 to April 1999. Prevalence varied from 22 to 50%, and monthly malaria attack incidence from 52 to 179‰. In each area, entomological variations were not related to parasite prevalence, but preceded malaria attack incidence with 1- or 2-month time lag, corresponding to the pre-patency period that differs in the two populations, possibly according to differences in immunity related to parasite transmission.
AB - To assess the relationships between variations of Plasmodium falciparum transmission and those of peripheral parasitaemia prevalence or malaria attack incidence rates in regions with limited fluctuations of transmission, we conducted a follow-up in two Gabonese populations. Entomological surveys were carried out from May 1995 to April 1996 in Dienga, and from May 1998 to April 1999 in Benguia. In Dienga, malaria transmission was seasonal, being not detected during two 3-month periods. Mean entomological inoculation rate (EIR) was 0.28 infective bite/person/night. In Benguia, malaria transmission was perennial with seasonal fluctuations, mean EIR being 0.76 infective bite/person/night. In Dienga, 301 schoolchildren were followed from October 1995 to March 1996. Clinical malaria attack was defined as fever associated with >5000 parasites/μl of blood. P. falciparum prevalence varied from 28 to 42%, and monthly malaria attack incidence from 30 to 169‰. In Benguia, the entire population (122 persons) was followed from November 1998 to April 1999. Prevalence varied from 22 to 50%, and monthly malaria attack incidence from 52 to 179‰. In each area, entomological variations were not related to parasite prevalence, but preceded malaria attack incidence with 1- or 2-month time lag, corresponding to the pre-patency period that differs in the two populations, possibly according to differences in immunity related to parasite transmission.
KW - Anopheles
KW - Gabon
KW - Malaria
KW - Malaria attack incidence
KW - Parasite prevalence
KW - Plasmodium falciparum
KW - Transmission
UR - http://www.scopus.com/inward/record.url?scp=0037345497&partnerID=8YFLogxK
U2 - 10.1016/S0001-706X(02)00266-8
DO - 10.1016/S0001-706X(02)00266-8
M3 - Article
C2 - 12659973
AN - SCOPUS:0037345497
SN - 0001-706X
VL - 85
SP - 355
EP - 361
JO - Acta Tropica
JF - Acta Tropica
IS - 3
ER -