TY - JOUR
T1 - Relationship between breast cancer and dietary inflammatory index; a case–control study
AU - Gholamalizadeh, Maryam
AU - Afsharfar, Maryam
AU - Fathi, Soroor
AU - Tajadod, Shirin
AU - Mohseni, Golsa Khalatbari
AU - Shekari, Soheila
AU - Vahid, Farhad
AU - Doaei, Saeid
AU - Shafaei Kachaei, Hanieh
AU - Majidi, Nazanin
AU - Kalantari, Naser
N1 - Funding Information:
This study was supported by funding from Student Research Committee of Shahid Beheshti University of Medical Sciences , Tehran. Iran (Code 1399/63386).
Publisher Copyright:
© 2022
PY - 2022/10
Y1 - 2022/10
N2 - Introduction: Breast cancer is the leading cause of cancer–related mortality among women around the world. The relationship between the inflammatory potential of diet and breast cancer has been studied extensively, but results remain inconsistent. This study aimed to investigate the association between the dietary inflammatory index (DII) and odds of breast cancer. Methods: This case–control study includes 180 women with breast cancer and 360 healthy women randomly selected from those referred to Shohadaye Tajrish hospital in Tehran, Iran. The DII scores were computed based on a 168-item food frequency questionnaire (FFQ) assessed based on dietary intake. After adjusting the potential confounders, logistic regression models were used to estimate multivariable odds ratios (ORs). Results: The positive association was found between DII and breast cancer risk. A higher level of DII was associated with a higher risk of developing breast cancer after being adjusted for age (OR: 2.11, 95% CI: 1.01–4.46, P = 0.04). Additional adjustments for BMI, alcohol consumption, smoking, pregnancy number, abortion number, breastfeeding duration, menopause age, and total calorie intake did not change the results (OR: 5.02, 95% CI: 1.43–17.58, P = 0.01). Conclusions: Following a pro-inflammatory diet was associated with an increased risk of BC. Further longitudinal studies are warranted.
AB - Introduction: Breast cancer is the leading cause of cancer–related mortality among women around the world. The relationship between the inflammatory potential of diet and breast cancer has been studied extensively, but results remain inconsistent. This study aimed to investigate the association between the dietary inflammatory index (DII) and odds of breast cancer. Methods: This case–control study includes 180 women with breast cancer and 360 healthy women randomly selected from those referred to Shohadaye Tajrish hospital in Tehran, Iran. The DII scores were computed based on a 168-item food frequency questionnaire (FFQ) assessed based on dietary intake. After adjusting the potential confounders, logistic regression models were used to estimate multivariable odds ratios (ORs). Results: The positive association was found between DII and breast cancer risk. A higher level of DII was associated with a higher risk of developing breast cancer after being adjusted for age (OR: 2.11, 95% CI: 1.01–4.46, P = 0.04). Additional adjustments for BMI, alcohol consumption, smoking, pregnancy number, abortion number, breastfeeding duration, menopause age, and total calorie intake did not change the results (OR: 5.02, 95% CI: 1.43–17.58, P = 0.01). Conclusions: Following a pro-inflammatory diet was associated with an increased risk of BC. Further longitudinal studies are warranted.
KW - Breast cancer
KW - Dietary inflammatory index (DII)
KW - Inflammation
KW - Nutritional assessment
UR - http://www.scopus.com/inward/record.url?scp=85136139007&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/36184227
U2 - 10.1016/j.clnesp.2022.08.001
DO - 10.1016/j.clnesp.2022.08.001
M3 - Article
C2 - 36184227
AN - SCOPUS:85136139007
SN - 2405-4577
VL - 51
SP - 353
EP - 358
JO - Clinical Nutrition ESPEN
JF - Clinical Nutrition ESPEN
ER -