TY - JOUR
T1 - Regulatory T cell metabolism at the intersection between autoimmune diseases and cancer
AU - Kurniawan, Henry
AU - Soriano-Baguet, Leticia
AU - Brenner, Dirk
N1 - Funding Information:
We acknowledge the valuable work of all investigators that we were unable to cite due to space limitations. The figures were created using Biorender.com. D.B. and H.K. are supported by the FNR-ATTRACT program (A14/BM/7632103) and D.B. by FNR-CORE (C18/BM/12691266). D.B. and L.S.B. are funded by the FNR-PRIDE (PRIDE/11012546/NEXTIMMUNE) scheme.
Funding Information:
We acknowledge the valuable work of all investigators that we were unable to cite due to space limitations. The figures were created using Biorender.com. D.B. and H.K. are supported by the FNR‐ATTRACT program (A14/BM/7632103) and D.B. by FNR‐CORE (C18/BM/12691266). D.B. and L.S.B. are funded by the FNR‐PRIDE (PRIDE/11012546/NEXTIMMUNE) scheme.
Publisher Copyright:
© 2020 The Authors. European Journal of Immunology published by Wiley-VCH GmbH
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Regulatory T cells (Tregs) are critical for peripheral immune tolerance and homeostasis, and altered Treg behavior is involved in many pathologies, including autoimmunity and cancer. The expression of the transcription factor FoxP3 in Tregs is fundamental to maintaining their stability and immunosuppressive function. Recent studies have highlighted the crucial role that metabolic reprogramming plays in controlling Treg plasticity, stability, and function. In this review, we summarize how the availability and use of various nutrients and metabolites influence Treg metabolic pathways and activity. We also discuss how Treg-intrinsic metabolic programs define and shape their differentiation, FoxP3 expression, and suppressive capacity. Lastly, we explore how manipulating the regulation of Treg metabolism might be exploited in different disease settings to achieve novel immunotherapies.
AB - Regulatory T cells (Tregs) are critical for peripheral immune tolerance and homeostasis, and altered Treg behavior is involved in many pathologies, including autoimmunity and cancer. The expression of the transcription factor FoxP3 in Tregs is fundamental to maintaining their stability and immunosuppressive function. Recent studies have highlighted the crucial role that metabolic reprogramming plays in controlling Treg plasticity, stability, and function. In this review, we summarize how the availability and use of various nutrients and metabolites influence Treg metabolic pathways and activity. We also discuss how Treg-intrinsic metabolic programs define and shape their differentiation, FoxP3 expression, and suppressive capacity. Lastly, we explore how manipulating the regulation of Treg metabolism might be exploited in different disease settings to achieve novel immunotherapies.
KW - autoimmunity
KW - cancer
KW - metabolism
KW - regulatory T cells
UR - http://www.scopus.com/inward/record.url?scp=85093847246&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/33067808
U2 - 10.1002/eji.201948470
DO - 10.1002/eji.201948470
M3 - Review article
C2 - 33067808
AN - SCOPUS:85093847246
SN - 0014-2980
VL - 50
SP - 1626
EP - 1642
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 11
ER -