Regulatory identification of BPA as an endocrine disruptor: Context and methodology

C. Beausoleil; C. Emond; J. P. Cravedi; J. P. Antignac; M. Applanat; B. M.R. Appenzeller; R. Beaudouin; L. P. Belzunces; M. C. Canivenc-Lavier; N. Chevalier; C. Chevrier; E. Elefant; F. Eustache; R. Habert; M. Kolf-Clauw; B. Le Magueresse-Battistoni; S. Mhaouty-Kodja; C. Minier; L. Multigner; H. Schroeder; P. Thonneau; C. Viguié; F. Pouzaud; J. N. Ormsby; C. Rousselle; L. Verines-Jouin; E. Pasquier; C. Michel

doi:10.1016/j.mce.2018.02.001

Regulatory identification of BPA as an endocrine disruptor: Context and methodology

C. Beausoleil, C. Emond, J. P. Cravedi, J. P. Antignac, M. Applanat, B. M.R. Appenzeller, R. Beaudouin, L. P. Belzunces, M. C. Canivenc-Lavier, N. Chevalier, C. Chevrier, E. Elefant, F. Eustache, R. Habert, M. Kolf-Clauw, B. Le Magueresse-Battistoni, S. Mhaouty-Kodja, C. Minier, L. Multigner, H. SchroederP. Thonneau, C. Viguié, F. Pouzaud, J. N. Ormsby, C. Rousselle, L. Verines-Jouin, E. Pasquier^*, C. Michel

^*Corresponding author for this work

Human Biomonitoring Research Unit

Research output: Contribution to journal › Review article › peer-review

86 Citations (Scopus)

Abstract

BPA is one of the most investigated substances for its endocrine disruptor (ED) properties and it is at the same time in the center of many ED-related controversies. The analysis on how BPA fits to the regulatory identification as an ED is a challenge in terms of methodology. It is also a great opportunity to test the regulatory framework with a uniquely data-rich substance and learn valuable lessons for future cases. From this extensive database, it was considered important to engage in a detailed analysis so as to provide specific and strong evidences of ED while reflecting accurately the complexity of the response as well the multiplicity of adverse effects. An appropriate delineation of the scope of the analysis was therefore critical. Four effects namely, alterations of estrous cyclicity, mammary gland development, brain development and memory function, and metabolism, were considered to provide solid evidence of ED-mediated effects of BPA.

Original language	English
Pages (from-to)	4-9
Number of pages	6
Journal	Molecular and Cellular Endocrinology
Volume	475
DOIs	https://doi.org/10.1016/j.mce.2018.02.001
Publication status	Published - 5 Nov 2018

Keywords

Bisphenol A
ED
Endocrine disruption
REACh
SVHC
Substance of very high concern

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10.1016/j.mce.2018.02.001

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Beausoleil, C., Emond, C., Cravedi, J. P., Antignac, J. P., Applanat, M., Appenzeller, B. M. R., Beaudouin, R., Belzunces, L. P., Canivenc-Lavier, M. C., Chevalier, N., Chevrier, C., Elefant, E., Eustache, F., Habert, R., Kolf-Clauw, M., Le Magueresse-Battistoni, B., Mhaouty-Kodja, S., Minier, C., Multigner, L., ... Michel, C. (2018). Regulatory identification of BPA as an endocrine disruptor: Context and methodology. Molecular and Cellular Endocrinology, 475, 4-9. https://doi.org/10.1016/j.mce.2018.02.001

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title = "Regulatory identification of BPA as an endocrine disruptor: Context and methodology",

abstract = "BPA is one of the most investigated substances for its endocrine disruptor (ED) properties and it is at the same time in the center of many ED-related controversies. The analysis on how BPA fits to the regulatory identification as an ED is a challenge in terms of methodology. It is also a great opportunity to test the regulatory framework with a uniquely data-rich substance and learn valuable lessons for future cases. From this extensive database, it was considered important to engage in a detailed analysis so as to provide specific and strong evidences of ED while reflecting accurately the complexity of the response as well the multiplicity of adverse effects. An appropriate delineation of the scope of the analysis was therefore critical. Four effects namely, alterations of estrous cyclicity, mammary gland development, brain development and memory function, and metabolism, were considered to provide solid evidence of ED-mediated effects of BPA.",

keywords = "Bisphenol A, ED, Endocrine disruption, REACh, SVHC, Substance of very high concern",

author = "C. Beausoleil and C. Emond and Cravedi, {J. P.} and Antignac, {J. P.} and M. Applanat and Appenzeller, {B. M.R.} and R. Beaudouin and Belzunces, {L. P.} and Canivenc-Lavier, {M. C.} and N. Chevalier and C. Chevrier and E. Elefant and F. Eustache and R. Habert and M. Kolf-Clauw and {Le Magueresse-Battistoni}, B. and S. Mhaouty-Kodja and C. Minier and L. Multigner and H. Schroeder and P. Thonneau and C. Vigui{\'e} and F. Pouzaud and Ormsby, {J. N.} and C. Rousselle and L. Verines-Jouin and E. Pasquier and C. Michel",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = nov,

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doi = "10.1016/j.mce.2018.02.001",

language = "English",

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Beausoleil, C, Emond, C, Cravedi, JP, Antignac, JP, Applanat, M, Appenzeller, BMR, Beaudouin, R, Belzunces, LP, Canivenc-Lavier, MC, Chevalier, N, Chevrier, C, Elefant, E, Eustache, F, Habert, R, Kolf-Clauw, M, Le Magueresse-Battistoni, B, Mhaouty-Kodja, S, Minier, C, Multigner, L, Schroeder, H, Thonneau, P, Viguié, C, Pouzaud, F, Ormsby, JN, Rousselle, C, Verines-Jouin, L, Pasquier, E & Michel, C 2018, 'Regulatory identification of BPA as an endocrine disruptor: Context and methodology', Molecular and Cellular Endocrinology, vol. 475, pp. 4-9. https://doi.org/10.1016/j.mce.2018.02.001

TY - JOUR

T1 - Regulatory identification of BPA as an endocrine disruptor

T2 - Context and methodology

AU - Beausoleil, C.

AU - Emond, C.

AU - Cravedi, J. P.

AU - Antignac, J. P.

AU - Applanat, M.

AU - Appenzeller, B. M.R.

AU - Beaudouin, R.

AU - Belzunces, L. P.

AU - Canivenc-Lavier, M. C.

AU - Chevalier, N.

AU - Chevrier, C.

AU - Elefant, E.

AU - Eustache, F.

AU - Habert, R.

AU - Kolf-Clauw, M.

AU - Le Magueresse-Battistoni, B.

AU - Mhaouty-Kodja, S.

AU - Minier, C.

AU - Multigner, L.

AU - Schroeder, H.

AU - Thonneau, P.

AU - Viguié, C.

AU - Pouzaud, F.

AU - Ormsby, J. N.

AU - Rousselle, C.

AU - Verines-Jouin, L.

AU - Pasquier, E.

AU - Michel, C.

PY - 2018/11/5

Y1 - 2018/11/5

N2 - BPA is one of the most investigated substances for its endocrine disruptor (ED) properties and it is at the same time in the center of many ED-related controversies. The analysis on how BPA fits to the regulatory identification as an ED is a challenge in terms of methodology. It is also a great opportunity to test the regulatory framework with a uniquely data-rich substance and learn valuable lessons for future cases. From this extensive database, it was considered important to engage in a detailed analysis so as to provide specific and strong evidences of ED while reflecting accurately the complexity of the response as well the multiplicity of adverse effects. An appropriate delineation of the scope of the analysis was therefore critical. Four effects namely, alterations of estrous cyclicity, mammary gland development, brain development and memory function, and metabolism, were considered to provide solid evidence of ED-mediated effects of BPA.

AB - BPA is one of the most investigated substances for its endocrine disruptor (ED) properties and it is at the same time in the center of many ED-related controversies. The analysis on how BPA fits to the regulatory identification as an ED is a challenge in terms of methodology. It is also a great opportunity to test the regulatory framework with a uniquely data-rich substance and learn valuable lessons for future cases. From this extensive database, it was considered important to engage in a detailed analysis so as to provide specific and strong evidences of ED while reflecting accurately the complexity of the response as well the multiplicity of adverse effects. An appropriate delineation of the scope of the analysis was therefore critical. Four effects namely, alterations of estrous cyclicity, mammary gland development, brain development and memory function, and metabolism, were considered to provide solid evidence of ED-mediated effects of BPA.

KW - Bisphenol A

KW - ED

KW - Endocrine disruption

KW - REACh

KW - SVHC

KW - Substance of very high concern

UR - http://www.scopus.com/inward/record.url?scp=85044538948&partnerID=8YFLogxK

U2 - 10.1016/j.mce.2018.02.001

DO - 10.1016/j.mce.2018.02.001

M3 - Review article

C2 - 29426018

AN - SCOPUS:85044538948

SN - 0303-7207

VL - 475

SP - 4

EP - 9

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

ER -

Regulatory identification of BPA as an endocrine disruptor: Context and methodology

Abstract

Keywords

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