Abstract
CD163, also referred to as M130, a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14(bright) CD16+ monocyte subset revealed the highest expression of CD163 among all monocyte subsets. CD163 mRNA and protein expression is up-regulated during macrophage colony- stimulating factor (M-CSF)-dependent phagocytic differentiation of human blood monocytes. In contrast, monocytic cells treated with GM-CSF and interleukin-4 (IL-4) for dendritic differentiation down-regulate this antigen. CD163 expression is also suppressed by proinflammatory mediators like lipopolysaccharide (LPS), interferon-γ (IFN-γ), and tumor necrosis factor α, whereas IL-6 and the antiinflammatory cytokine interleukin- 10 (IL-10) strongly up-regulate CD163 mRNA in monocytes and macrophages. The effects of the immunosuppressants dexamethasone, cyclosporin A (CA), and cortisol differ in their capacity to influence CD163 mRNA levels. Our results demonstrate that CD163 expression in monocytes/macrophages is regulated by proinflammatory and antiinflammatory mediators. This expression pattern implies a functional role of CD163 in the antiinflammatory response of monocytes.
Original language | English |
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Pages (from-to) | 97-103 |
Number of pages | 7 |
Journal | Journal of Leukocyte Biology |
Volume | 67 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2000 |
Externally published | Yes |
Keywords
- Inflammation
- Interferon-γ
- Interleukin-10
- Tumor necrosis factor α