Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli

Christa Buechler*, Mirko Ritter, Evelyn Orsó, Thomas Langmann, Jochen Klucken, Gerd Schmitz

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

554 Citations (Scopus)

Abstract

CD163, also referred to as M130, a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14(bright) CD16+ monocyte subset revealed the highest expression of CD163 among all monocyte subsets. CD163 mRNA and protein expression is up-regulated during macrophage colony- stimulating factor (M-CSF)-dependent phagocytic differentiation of human blood monocytes. In contrast, monocytic cells treated with GM-CSF and interleukin-4 (IL-4) for dendritic differentiation down-regulate this antigen. CD163 expression is also suppressed by proinflammatory mediators like lipopolysaccharide (LPS), interferon-γ (IFN-γ), and tumor necrosis factor α, whereas IL-6 and the antiinflammatory cytokine interleukin- 10 (IL-10) strongly up-regulate CD163 mRNA in monocytes and macrophages. The effects of the immunosuppressants dexamethasone, cyclosporin A (CA), and cortisol differ in their capacity to influence CD163 mRNA levels. Our results demonstrate that CD163 expression in monocytes/macrophages is regulated by proinflammatory and antiinflammatory mediators. This expression pattern implies a functional role of CD163 in the antiinflammatory response of monocytes.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalJournal of Leukocyte Biology
Volume67
Issue number1
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Inflammation
  • Interferon-γ
  • Interleukin-10
  • Tumor necrosis factor α

Fingerprint

Dive into the research topics of 'Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli'. Together they form a unique fingerprint.

Cite this