Regulation of microRNAs in coronary atherosclerotic plaque

Öcal Berkan, Serdal Arslan, Torkia Lalem, Lu Zhang, Nil Özbilum Şahin, Eylem Itlr Aydemir, Özge Korkmaz, Hatice Reyhan Eǧilmez, Nilgün Çekin, Yvan Devaux*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Aim: Identification of microRNAs (miRNAs) associated with atherosclerosis may unravel novel therapeutic targets and biomarkers. We studied miRNAs differentially expressed between coronary atherosclerotic plaques (CAP) and healthy arteries. Materials & methods: Paired CAP and internal mammary arteries (IMA) were collected from 14 coronary artery disease patients. The miRNA profiles between diseased (CAP) and healthy (IMA) tissues were compared using microarrays and quantitative PCR. Results: Thirty-one miRNAs were differentially expressed between CAP and IMA. Among these, miR-486-5p showed a high level of regulation (12-fold), had predicted interactions with atherosclerosis-associated genes and correlated with triglyceride levels and arterial stenosis. Regulation of miR-486-5p was validated by PCR (p = 0.004). Conclusion: The miRNAs are regulated in the atherosclerotic plaque. We highlight miR-486-5p whose role in atherosclerosis requires further investigation.

Original languageEnglish
Pages (from-to)1387-1397
Number of pages11
JournalEpigenomics
Volume11
Issue number12
DOIs
Publication statusPublished - 2019

Keywords

  • atherosclerosis
  • atherosclerotic plaque
  • coronary artery disease
  • microRNAs

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