@article{180ed30c66cd45f782f11197f0d6fd5f,
title = "Regulation of microRNAs in coronary atherosclerotic plaque",
abstract = "Aim: Identification of microRNAs (miRNAs) associated with atherosclerosis may unravel novel therapeutic targets and biomarkers. We studied miRNAs differentially expressed between coronary atherosclerotic plaques (CAP) and healthy arteries. Materials & methods: Paired CAP and internal mammary arteries (IMA) were collected from 14 coronary artery disease patients. The miRNA profiles between diseased (CAP) and healthy (IMA) tissues were compared using microarrays and quantitative PCR. Results: Thirty-one miRNAs were differentially expressed between CAP and IMA. Among these, miR-486-5p showed a high level of regulation (12-fold), had predicted interactions with atherosclerosis-associated genes and correlated with triglyceride levels and arterial stenosis. Regulation of miR-486-5p was validated by PCR (p = 0.004). Conclusion: The miRNAs are regulated in the atherosclerotic plaque. We highlight miR-486-5p whose role in atherosclerosis requires further investigation.",
keywords = "atherosclerosis, atherosclerotic plaque, coronary artery disease, microRNAs",
author = "{\"O}cal Berkan and Serdal Arslan and Torkia Lalem and Lu Zhang and {\c S}ahin, {Nil {\"O}zbilum} and Aydemir, {Eylem Itlr} and {\"O}zge Korkmaz and Eǧilmez, {Hatice Reyhan} and Nilg{\"u}n {\c C}ekin and Yvan Devaux",
note = "Funding Information: This paper is based upon collaboration supported by the European Union Cooperation in Science and Technology (COST) Action EU-CardioRNA CA17129. Funding Information: The present study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK, project no: 214S031, project code: 1001), Ankara, Turkey. T Lalem, Y Devaux and L Zhang are supported by the Ministry of Higher Education and Research and the Society for Research on Cardiovascular Diseases of Luxembourg. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Funding Information: The present study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK, project no: 214S031, project code: 1001), Ankara, Turkey. T Lalem, Y Devaux and L Zhang are supported by the Ministry of Higher Education and Research and the Society for Research on Cardiovascular Diseases of Luxembourg. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: {\textcopyright} 2019 Future Medicine Ltd.",
year = "2019",
doi = "10.2217/epi-2019-0036",
language = "English",
volume = "11",
pages = "1387--1397",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "12",
}